Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model
Joint Authors
Jiang, Yiping
Zhang, Hong
Zhang, Yan
Han, Hai-Yan
Peng, Cheng
He, Kun
Qin, Lu-Ping
Rahman, Khalid
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hypertrophic scarring is a common proliferative disorder of dermal fibroblasts characterized by collagen overproduction and excessive deposition of extracellular matrix (ECM).
There is no consensus about the best therapeutics to produce complete and permanent improvement of scars with few side effects.
To investigate the therapeutic effects of oleanolic acid (OA) on hypertrophic scars and explore the possible mechanism of action involved, a rabbit ear model with hypertrophic scars was established.
OA (2.5%, 5%, and 10%) was given once daily to the scars for 28 consecutive days.
As a result, OA significantly alleviated formed hypertrophic scars on rabbit ears.
The levels of TGF-β1, MMP-1, TIMP-1, and collagens I and III were notably decreased, and the number of apoptosis cells and mRNA expression of MMP-2, caspase-3, and caspase-9 were markedly increased in the scar tissue.
The scar elevation index (SEI) was also evidently reduced.
Histological findings exhibited significant amelioration of the collagen tissue.
These results suggest that OA has the favorable curative effects on formed hypertrophic scars in the rabbit ear model, and the possible mechanism of action is that OA decreases HSFs proliferation and increases HSFs apoptosis by reduction of P311 gene expression and TGF-β1 production, inhibition of TIMP-1 secretion, enhancement of MMP-2 activity, and subsequently facilitation of degradation of collagen types I and III.
American Psychological Association (APA)
Zhang, Hong& Zhang, Yan& Jiang, Yiping& Han, Hai-Yan& Peng, Cheng& He, Kun…[et al.]. 2012. Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028574
Modern Language Association (MLA)
Zhang, Hong…[et al.]. Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028574
American Medical Association (AMA)
Zhang, Hong& Zhang, Yan& Jiang, Yiping& Han, Hai-Yan& Peng, Cheng& He, Kun…[et al.]. Curative Effects of Oleanolic Acid on Formed Hypertrophic Scars in the Rabbit Ear Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028574