Proteomic Analysis Reveals the Deregulation of Inflammation-Related Proteins in Acupuncture-Treated Rats with Asthma Onset

المؤلفون المشاركون

Xu, Yu-Dong
Cui, Jian-Mei
Wei, Ying
Gao, Chang-Ke
Liu, Xiao-Yan
Shan, Chun-Xiao
Jiang, Yong-Liang
Yang, Yong Qing
Lui, Yan-Yan
Yin, Lei-Miao
Wang, Yu

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-11-14

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الطب البشري

الملخص EN

Although the beneficial effects of acupuncture in asthma treatment have been well documented, little is known regarding the biological basis of this treatment.

Changes in the lung proteome of acupuncture-treated rats with asthma onset were comparatively analyzed using a two-dimensional gel electrophoresis (2DE) and mass-spectrometry- (MS-) based proteomic approach.

Acupuncture on specific acupuncture points appeared to improve respiratory function and reduce the total number of leukocytes and eosinophils in bronchoalveolar lavage fluid in OVA-induced asthma onset.

Image analysis of 2DE gels revealed 32 differentially expressed acupuncture-specific protein spots in asthma onset; 30 of which were successfully identified as 28 unique proteins using LC-MS/MS.

Bioinformatic analyses indicated that these altered proteins are most likely involved in inflammation-related biological functions, and the functional associations of these proteins result in an inflammation signaling pathway.

Acupuncture regulates the pathway at different levels by regulating several key nodal proteins, including downregulating of proinflammatory proteins (e.g., S100A8, RAGE, and S100A11) and upregulating of anti-inflammatory proteins (e.g., CC10, ANXA5, and sRAGE).

These deregulated inflammation-related proteins may mediate, at least in part, the antiasthmatic effect of acupuncture.

Further functional investigation of these acupuncture-specific effector proteins could identify new drug candidates for the prophylaxis and treatment of asthma.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Xu, Yu-Dong& Cui, Jian-Mei& Wang, Yu& Yin, Lei-Miao& Gao, Chang-Ke& Liu, Xiao-Yan…[et al.]. 2012. Proteomic Analysis Reveals the Deregulation of Inflammation-Related Proteins in Acupuncture-Treated Rats with Asthma Onset. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028583

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Xu, Yu-Dong…[et al.]. Proteomic Analysis Reveals the Deregulation of Inflammation-Related Proteins in Acupuncture-Treated Rats with Asthma Onset. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1028583

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Xu, Yu-Dong& Cui, Jian-Mei& Wang, Yu& Yin, Lei-Miao& Gao, Chang-Ke& Liu, Xiao-Yan…[et al.]. Proteomic Analysis Reveals the Deregulation of Inflammation-Related Proteins in Acupuncture-Treated Rats with Asthma Onset. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028583

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1028583