Stimulation of TRPV1 by Green Laser Light

المؤلفون المشاركون

Schwarz, Wolfgang
Gu, Quanbao
Huang, Fang
Wang, Lina

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-12-17

دولة النشر

مصر

عدد الصفحات

8

التخصصات الرئيسية

الطب البشري

الملخص EN

Low-level laser irradiation of visible light had been introduced as a medical treatment already more than 40 years ago, but itsmedical application still remains controversial.

Laser stimulation of acupuncture points has also been introduced, and mast-cells degranulation has been suggested.

Activation of TRPV ion channels may be involved in the degranulation.

Here, we investigated whether TRPV1 could serve as candidate for laser-induced mast cell activation.

Activation of TRPV1 by capsaicin resulted in degranulation.

To investigate the effect of laser irradiation on TRPV1, we used the Xenopus oocyte as expression and model system.

We show that TRPV1 can functionally be expressed in the oocyte by(a) activation by capsaicin (K1/2 = 1.1 μM), (b) activation by temperatures exceeding 42°C, (c) activation byreduced pH (from 7.4 to 6.2), and (d) inhibition by ruthenium red.

Red (637 nm) as well as blue (406 nm)light neither affected membrane currents in oocytes nor did it modulate capsaicin-induced current.

In contrast, green laser light (532 nm) produced power-dependent activation of TRPV1.

In conclusion, we could showthat green light is effective at the cellular level to activate TRPV1.

To which extend green light is of medical relevance needs furtherinvestigation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Gu, Quanbao& Wang, Lina& Huang, Fang& Schwarz, Wolfgang. 2012. Stimulation of TRPV1 by Green Laser Light. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028588

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Gu, Quanbao…[et al.]. Stimulation of TRPV1 by Green Laser Light. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028588

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Gu, Quanbao& Wang, Lina& Huang, Fang& Schwarz, Wolfgang. Stimulation of TRPV1 by Green Laser Light. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028588

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1028588