Stimulation of TRPV1 by Green Laser Light
Joint Authors
Schwarz, Wolfgang
Gu, Quanbao
Huang, Fang
Wang, Lina
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Low-level laser irradiation of visible light had been introduced as a medical treatment already more than 40 years ago, but itsmedical application still remains controversial.
Laser stimulation of acupuncture points has also been introduced, and mast-cells degranulation has been suggested.
Activation of TRPV ion channels may be involved in the degranulation.
Here, we investigated whether TRPV1 could serve as candidate for laser-induced mast cell activation.
Activation of TRPV1 by capsaicin resulted in degranulation.
To investigate the effect of laser irradiation on TRPV1, we used the Xenopus oocyte as expression and model system.
We show that TRPV1 can functionally be expressed in the oocyte by(a) activation by capsaicin (K1/2 = 1.1 μM), (b) activation by temperatures exceeding 42°C, (c) activation byreduced pH (from 7.4 to 6.2), and (d) inhibition by ruthenium red.
Red (637 nm) as well as blue (406 nm)light neither affected membrane currents in oocytes nor did it modulate capsaicin-induced current.
In contrast, green laser light (532 nm) produced power-dependent activation of TRPV1.
In conclusion, we could showthat green light is effective at the cellular level to activate TRPV1.
To which extend green light is of medical relevance needs furtherinvestigation.
American Psychological Association (APA)
Gu, Quanbao& Wang, Lina& Huang, Fang& Schwarz, Wolfgang. 2012. Stimulation of TRPV1 by Green Laser Light. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028588
Modern Language Association (MLA)
Gu, Quanbao…[et al.]. Stimulation of TRPV1 by Green Laser Light. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028588
American Medical Association (AMA)
Gu, Quanbao& Wang, Lina& Huang, Fang& Schwarz, Wolfgang. Stimulation of TRPV1 by Green Laser Light. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028588
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028588