Study of the Effects of Monacolin K and Other Constituents of Red Yeast Rice on Obesity, Insulin-Resistance, Hyperlipidemia, and Nonalcoholic Steatohepatitis Using a Mouse Model of Metabolic Syndrome
المؤلفون المشاركون
Tsuneyama, Koichi
Chen, Jiun-Liang
Chen, Shao-Yuan
Chen, Yen-Chen
Shimada, Yutaka
Nishida, Takeshi
Fujimoto, Makoto
Murakami, Jun
Fujimoto, Takako
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-20
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Purpose.
Nonalcoholic fatty liver disease (NAFLD) is a progressive and intractable disease associated with metabolic syndrome.
Red yeast rice (RYR) contains monacolin K, a potent inhibitor of HMG-CoA reductase, and its consumption decreases cholesterol and triglyceride levels.
We examined the efficacy of RYR constituents using a novel metabolic syndrome-NAFLD mouse model (MSG mice).
Methods.
Two types of RYR grown under different culture conditions were used.
1P-DU contained only 0.002 g/100 g of monacolin K, whereas 3P-D1 contained 0.131 g/100 g.
MSG mice were divided into three groups: control (C) group fed standard food, RYR-C group fed standard food with 1% 1P-DU, and RYR-M group fed standard food with 1% 3P-D1.
Mice were examined from 12 to 24 weeks of age.
Results.
Serum insulin, leptin, and liver damage as well as macrophage aggregation in visceral fat in RYR-C and RYR-M groups were lower than those in C group.
The serum adiponectin levels in RYR-C group were significantly higher than those in RYR-M and C groups.
Conclusions.
RYR was effective against obesity-related inflammation, insulin resistance, and NAFLD in MSG mice irrespective of monacolin K levels.
GABA and various peptides produced during fermentation were determined as the active constituents of RYR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fujimoto, Makoto& Tsuneyama, Koichi& Chen, Shao-Yuan& Nishida, Takeshi& Chen, Jiun-Liang& Chen, Yen-Chen…[et al.]. 2012. Study of the Effects of Monacolin K and Other Constituents of Red Yeast Rice on Obesity, Insulin-Resistance, Hyperlipidemia, and Nonalcoholic Steatohepatitis Using a Mouse Model of Metabolic Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028602
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fujimoto, Makoto…[et al.]. Study of the Effects of Monacolin K and Other Constituents of Red Yeast Rice on Obesity, Insulin-Resistance, Hyperlipidemia, and Nonalcoholic Steatohepatitis Using a Mouse Model of Metabolic Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028602
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fujimoto, Makoto& Tsuneyama, Koichi& Chen, Shao-Yuan& Nishida, Takeshi& Chen, Jiun-Liang& Chen, Yen-Chen…[et al.]. Study of the Effects of Monacolin K and Other Constituents of Red Yeast Rice on Obesity, Insulin-Resistance, Hyperlipidemia, and Nonalcoholic Steatohepatitis Using a Mouse Model of Metabolic Syndrome. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028602
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028602
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر