Study of the Effects of Monacolin K and Other Constituents of Red Yeast Rice on Obesity, Insulin-Resistance, Hyperlipidemia, and Nonalcoholic Steatohepatitis Using a Mouse Model of Metabolic Syndrome
Joint Authors
Tsuneyama, Koichi
Chen, Jiun-Liang
Chen, Shao-Yuan
Chen, Yen-Chen
Shimada, Yutaka
Nishida, Takeshi
Fujimoto, Makoto
Murakami, Jun
Fujimoto, Takako
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
Nonalcoholic fatty liver disease (NAFLD) is a progressive and intractable disease associated with metabolic syndrome.
Red yeast rice (RYR) contains monacolin K, a potent inhibitor of HMG-CoA reductase, and its consumption decreases cholesterol and triglyceride levels.
We examined the efficacy of RYR constituents using a novel metabolic syndrome-NAFLD mouse model (MSG mice).
Methods.
Two types of RYR grown under different culture conditions were used.
1P-DU contained only 0.002 g/100 g of monacolin K, whereas 3P-D1 contained 0.131 g/100 g.
MSG mice were divided into three groups: control (C) group fed standard food, RYR-C group fed standard food with 1% 1P-DU, and RYR-M group fed standard food with 1% 3P-D1.
Mice were examined from 12 to 24 weeks of age.
Results.
Serum insulin, leptin, and liver damage as well as macrophage aggregation in visceral fat in RYR-C and RYR-M groups were lower than those in C group.
The serum adiponectin levels in RYR-C group were significantly higher than those in RYR-M and C groups.
Conclusions.
RYR was effective against obesity-related inflammation, insulin resistance, and NAFLD in MSG mice irrespective of monacolin K levels.
GABA and various peptides produced during fermentation were determined as the active constituents of RYR.
American Psychological Association (APA)
Fujimoto, Makoto& Tsuneyama, Koichi& Chen, Shao-Yuan& Nishida, Takeshi& Chen, Jiun-Liang& Chen, Yen-Chen…[et al.]. 2012. Study of the Effects of Monacolin K and Other Constituents of Red Yeast Rice on Obesity, Insulin-Resistance, Hyperlipidemia, and Nonalcoholic Steatohepatitis Using a Mouse Model of Metabolic Syndrome. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028602
Modern Language Association (MLA)
Fujimoto, Makoto…[et al.]. Study of the Effects of Monacolin K and Other Constituents of Red Yeast Rice on Obesity, Insulin-Resistance, Hyperlipidemia, and Nonalcoholic Steatohepatitis Using a Mouse Model of Metabolic Syndrome. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028602
American Medical Association (AMA)
Fujimoto, Makoto& Tsuneyama, Koichi& Chen, Shao-Yuan& Nishida, Takeshi& Chen, Jiun-Liang& Chen, Yen-Chen…[et al.]. Study of the Effects of Monacolin K and Other Constituents of Red Yeast Rice on Obesity, Insulin-Resistance, Hyperlipidemia, and Nonalcoholic Steatohepatitis Using a Mouse Model of Metabolic Syndrome. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028602