Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors
المؤلفون المشاركون
Patil, Sumersing
Jabgunde, Amit
Ghosh, Sougata
Bhat, Menakshi
Joshi, Bimba N.
Jachak, Sanjay
Ahire, Mehul
Chopade, Balu A.
Pardesi, Karishma
Dhavale, Dilip D.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Diabetes is a metabolic disorder affecting about 220 million people worldwide.
One of the most critical complications of diabetes is post-prandial hyper-glycemia (PPHG).
Glucosidase inhibitor and α-amylase inhibitors are class of compounds that help in managing PPHG.
Low-cost herbal treatment is recommended due to their lesser side effect for treatment of diabetes.
Two plants with significant traditional therapeutic potential, namely, Gnidia glauca and Dioscorea bulbifera, were tested for their efficiency to inhibit α-amylase and α-glucosidase.
Stem, leaf, and flower of G.
glauca and bulb of D.
bulbifera were sequentially extracted with petroleum ether, ethyl acetate, and methanol as well as separately with 70% ethanol.
Petroleum ether extract of flower of G.
glauca was found to inhibit α-amylase significantly (78.56%).
Extracts were further tested against crude murine pancreatic, small intestinal, and liver glucosidase enzyme which revealed excellent inhibitory properties.
α-glucosidase inhibition provided a strong in vitro evidence for confirmation of both G.
glauca and D.
bulbifera as excellent antidiabetic remedy.
This is the first report of its kind that provides a strong biochemical basis for management of type II diabetes using G.
glauca and D.
bulbifera.
These results provide intense rationale for further in vivo and clinical study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ghosh, Sougata& Ahire, Mehul& Patil, Sumersing& Jabgunde, Amit& Bhat, Menakshi& Joshi, Bimba N.…[et al.]. 2011. Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028626
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ghosh, Sougata…[et al.]. Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028626
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ghosh, Sougata& Ahire, Mehul& Patil, Sumersing& Jabgunde, Amit& Bhat, Menakshi& Joshi, Bimba N.…[et al.]. Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028626
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028626
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر