Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors
Joint Authors
Patil, Sumersing
Jabgunde, Amit
Ghosh, Sougata
Bhat, Menakshi
Joshi, Bimba N.
Jachak, Sanjay
Ahire, Mehul
Chopade, Balu A.
Pardesi, Karishma
Dhavale, Dilip D.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetes is a metabolic disorder affecting about 220 million people worldwide.
One of the most critical complications of diabetes is post-prandial hyper-glycemia (PPHG).
Glucosidase inhibitor and α-amylase inhibitors are class of compounds that help in managing PPHG.
Low-cost herbal treatment is recommended due to their lesser side effect for treatment of diabetes.
Two plants with significant traditional therapeutic potential, namely, Gnidia glauca and Dioscorea bulbifera, were tested for their efficiency to inhibit α-amylase and α-glucosidase.
Stem, leaf, and flower of G.
glauca and bulb of D.
bulbifera were sequentially extracted with petroleum ether, ethyl acetate, and methanol as well as separately with 70% ethanol.
Petroleum ether extract of flower of G.
glauca was found to inhibit α-amylase significantly (78.56%).
Extracts were further tested against crude murine pancreatic, small intestinal, and liver glucosidase enzyme which revealed excellent inhibitory properties.
α-glucosidase inhibition provided a strong in vitro evidence for confirmation of both G.
glauca and D.
bulbifera as excellent antidiabetic remedy.
This is the first report of its kind that provides a strong biochemical basis for management of type II diabetes using G.
glauca and D.
bulbifera.
These results provide intense rationale for further in vivo and clinical study.
American Psychological Association (APA)
Ghosh, Sougata& Ahire, Mehul& Patil, Sumersing& Jabgunde, Amit& Bhat, Menakshi& Joshi, Bimba N.…[et al.]. 2011. Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028626
Modern Language Association (MLA)
Ghosh, Sougata…[et al.]. Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028626
American Medical Association (AMA)
Ghosh, Sougata& Ahire, Mehul& Patil, Sumersing& Jabgunde, Amit& Bhat, Menakshi& Joshi, Bimba N.…[et al.]. Antidiabetic Activity of Gnidia glauca and Dioscorea bulbifera: Potent Amylase and Glucosidase Inhibitors. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028626
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028626