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Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta
المؤلفون المشاركون
Ghedini, Paulo César
Oliveira, Lais Moraes de
Rodrigues, Aline Gabriela
Silva, Elaine Fernanda da
Cerqueira, Letícia Bonancio
Pedrino, Gustavo Rodrigues
Pontarolo, Roberto
Campos, Francinete Ramos
Filgueira, Fernando Paranaiba
de Carvalho, Maria Helena Catelli
Castro, Carlos Henrique
Costa, Elson Alves
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Caryocar brasiliense Camb.
“pequi” is a native plant from the Cerrado region of Brazil that contains bioactive components reported to be antioxidant agents.
Previous work has demonstrated that dietary supplementation with pequi decreased the arterial pressure of volunteer athletes.
We found that the crude hydroalcoholic extract (CHE) of C.
brasiliense leaves relaxed, in a concentration-dependent manner, rat aortic rings precontracted with phenylephrine, and that the butanolic fraction (BF) produced an effect similar to that of the CHE.
Aortic relaxation induced by BF was abolished by endothelium removal, by incubation of the nitric oxide synthase inhibitor L-NAME, or the soluble guanylatecyclase inhibitor ODQ.
However, incubation with atropine and pyrilamine had no effect on the BF-induced vasorelaxation.
Moreover, this effect was not inhibited by indomethacin and tetraethylammonium.
The concentration-response curve to calcium in denuded-endothelium rings was not modified after incubation with BF, and the vasorelaxation by BF in endothelium-intact rings precontracted with KCl was abolished after incubation with L-NAME.
In addition, administration of BF in anesthetized rats resulted in a reversible hypotension.
The results reveal that C.
brasiliense possesses both in vivo and in vitro activities and that the vascular effect of BF involves stimulation of the nitric oxide/cyclic GMP pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Oliveira, Lais Moraes de& Rodrigues, Aline Gabriela& Silva, Elaine Fernanda da& Cerqueira, Letícia Bonancio& Castro, Carlos Henrique& Pedrino, Gustavo Rodrigues…[et al.]. 2012. Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028633
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Oliveira, Lais Moraes de…[et al.]. Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028633
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Oliveira, Lais Moraes de& Rodrigues, Aline Gabriela& Silva, Elaine Fernanda da& Cerqueira, Letícia Bonancio& Castro, Carlos Henrique& Pedrino, Gustavo Rodrigues…[et al.]. Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028633
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028633
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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