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Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta
Joint Authors
Ghedini, Paulo César
Oliveira, Lais Moraes de
Rodrigues, Aline Gabriela
Silva, Elaine Fernanda da
Cerqueira, Letícia Bonancio
Pedrino, Gustavo Rodrigues
Pontarolo, Roberto
Campos, Francinete Ramos
Filgueira, Fernando Paranaiba
de Carvalho, Maria Helena Catelli
Castro, Carlos Henrique
Costa, Elson Alves
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-15
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Caryocar brasiliense Camb.
“pequi” is a native plant from the Cerrado region of Brazil that contains bioactive components reported to be antioxidant agents.
Previous work has demonstrated that dietary supplementation with pequi decreased the arterial pressure of volunteer athletes.
We found that the crude hydroalcoholic extract (CHE) of C.
brasiliense leaves relaxed, in a concentration-dependent manner, rat aortic rings precontracted with phenylephrine, and that the butanolic fraction (BF) produced an effect similar to that of the CHE.
Aortic relaxation induced by BF was abolished by endothelium removal, by incubation of the nitric oxide synthase inhibitor L-NAME, or the soluble guanylatecyclase inhibitor ODQ.
However, incubation with atropine and pyrilamine had no effect on the BF-induced vasorelaxation.
Moreover, this effect was not inhibited by indomethacin and tetraethylammonium.
The concentration-response curve to calcium in denuded-endothelium rings was not modified after incubation with BF, and the vasorelaxation by BF in endothelium-intact rings precontracted with KCl was abolished after incubation with L-NAME.
In addition, administration of BF in anesthetized rats resulted in a reversible hypotension.
The results reveal that C.
brasiliense possesses both in vivo and in vitro activities and that the vascular effect of BF involves stimulation of the nitric oxide/cyclic GMP pathway.
American Psychological Association (APA)
Oliveira, Lais Moraes de& Rodrigues, Aline Gabriela& Silva, Elaine Fernanda da& Cerqueira, Letícia Bonancio& Castro, Carlos Henrique& Pedrino, Gustavo Rodrigues…[et al.]. 2012. Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028633
Modern Language Association (MLA)
Oliveira, Lais Moraes de…[et al.]. Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028633
American Medical Association (AMA)
Oliveira, Lais Moraes de& Rodrigues, Aline Gabriela& Silva, Elaine Fernanda da& Cerqueira, Letícia Bonancio& Castro, Carlos Henrique& Pedrino, Gustavo Rodrigues…[et al.]. Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028633