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Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model
المؤلفون المشاركون
Lin, Hsueh-Yi
Yang, Ying-Chen
Chen, Chien-Hsu
Yu, Yung-Lung
Lin, Chai-Ching
Yan, Hong-Young
Su, Kuo-Jung
Yu, Sung-Liang
Chen, Yi-Lin Sophia
Su, Kang-Yi
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-16
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Saussurea involucrata (Kar.
et Kir.), known as the snow lotus, grows in the Tian Shan and A’er Tai areas of China.
It has recently been reported that the ethyl acetate extract of S.
involucrata (SI-2) can inhibit proliferation and induce apoptosis in PC-3 human prostate cancer cells.
This study investigated the protective effect of ethyl acetate extract of S.
involucrata (SI-2) or rutin, a flavonoid extracted from ethyl acetate extract of S.
involucrata (SI-2), on D-galactose- (D-gal-) induced brain injury in mice.
Administering SI-2 or rutin (30 mg/kg/d and 30 mg/kg/d) for 6 weeks, concomitant with D-gal injection, significantly increased superoxide dismutase and glutathione peroxidase activities and decreased the MDA level in plasma.
Furthermore, the result showed that the percentages of cleaved caspase-3 and PARP in the D-gal-treated mice were much higher than those in the control.
Pretreatment using SI-2 or rutin decreased the expression of cyclooxygenase-2 via downregulation of NF-kappaB, resulting in a decrease in lipid peroxidation.
Furthermore, our results also showed that oral administration of rutin to these mice significantly improved behavioral performance in a step-through passive avoidance task and these results suggest that SI-2 or rutin exerts potent antiaging effects on D-gal in mice via antioxidative mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Ying-Chen& Lin, Hsueh-Yi& Su, Kang-Yi& Chen, Chien-Hsu& Yu, Yung-Lung& Lin, Chai-Ching…[et al.]. 2012. Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028664
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Ying-Chen…[et al.]. Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028664
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Ying-Chen& Lin, Hsueh-Yi& Su, Kang-Yi& Chen, Chien-Hsu& Yu, Yung-Lung& Lin, Chai-Ching…[et al.]. Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028664
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028664
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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