Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model

Joint Authors

Lin, Hsueh-Yi
Yang, Ying-Chen
Chen, Chien-Hsu
Yu, Yung-Lung
Lin, Chai-Ching
Yan, Hong-Young
Su, Kuo-Jung
Yu, Sung-Liang
Chen, Yi-Lin Sophia
Su, Kang-Yi

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-08-16

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

Saussurea involucrata (Kar.

et Kir.), known as the snow lotus, grows in the Tian Shan and A’er Tai areas of China.

It has recently been reported that the ethyl acetate extract of S.

involucrata (SI-2) can inhibit proliferation and induce apoptosis in PC-3 human prostate cancer cells.

This study investigated the protective effect of ethyl acetate extract of S.

involucrata (SI-2) or rutin, a flavonoid extracted from ethyl acetate extract of S.

involucrata (SI-2), on D-galactose- (D-gal-) induced brain injury in mice.

Administering SI-2 or rutin (30 mg/kg/d and 30 mg/kg/d) for 6 weeks, concomitant with D-gal injection, significantly increased superoxide dismutase and glutathione peroxidase activities and decreased the MDA level in plasma.

Furthermore, the result showed that the percentages of cleaved caspase-3 and PARP in the D-gal-treated mice were much higher than those in the control.

Pretreatment using SI-2 or rutin decreased the expression of cyclooxygenase-2 via downregulation of NF-kappaB, resulting in a decrease in lipid peroxidation.

Furthermore, our results also showed that oral administration of rutin to these mice significantly improved behavioral performance in a step-through passive avoidance task and these results suggest that SI-2 or rutin exerts potent antiaging effects on D-gal in mice via antioxidative mechanisms.

American Psychological Association (APA)

Yang, Ying-Chen& Lin, Hsueh-Yi& Su, Kang-Yi& Chen, Chien-Hsu& Yu, Yung-Lung& Lin, Chai-Ching…[et al.]. 2012. Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028664

Modern Language Association (MLA)

Yang, Ying-Chen…[et al.]. Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028664

American Medical Association (AMA)

Yang, Ying-Chen& Lin, Hsueh-Yi& Su, Kang-Yi& Chen, Chien-Hsu& Yu, Yung-Lung& Lin, Chai-Ching…[et al.]. Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028664

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1028664