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Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model
Joint Authors
Lin, Hsueh-Yi
Yang, Ying-Chen
Chen, Chien-Hsu
Yu, Yung-Lung
Lin, Chai-Ching
Yan, Hong-Young
Su, Kuo-Jung
Yu, Sung-Liang
Chen, Yi-Lin Sophia
Su, Kang-Yi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-16
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Saussurea involucrata (Kar.
et Kir.), known as the snow lotus, grows in the Tian Shan and A’er Tai areas of China.
It has recently been reported that the ethyl acetate extract of S.
involucrata (SI-2) can inhibit proliferation and induce apoptosis in PC-3 human prostate cancer cells.
This study investigated the protective effect of ethyl acetate extract of S.
involucrata (SI-2) or rutin, a flavonoid extracted from ethyl acetate extract of S.
involucrata (SI-2), on D-galactose- (D-gal-) induced brain injury in mice.
Administering SI-2 or rutin (30 mg/kg/d and 30 mg/kg/d) for 6 weeks, concomitant with D-gal injection, significantly increased superoxide dismutase and glutathione peroxidase activities and decreased the MDA level in plasma.
Furthermore, the result showed that the percentages of cleaved caspase-3 and PARP in the D-gal-treated mice were much higher than those in the control.
Pretreatment using SI-2 or rutin decreased the expression of cyclooxygenase-2 via downregulation of NF-kappaB, resulting in a decrease in lipid peroxidation.
Furthermore, our results also showed that oral administration of rutin to these mice significantly improved behavioral performance in a step-through passive avoidance task and these results suggest that SI-2 or rutin exerts potent antiaging effects on D-gal in mice via antioxidative mechanisms.
American Psychological Association (APA)
Yang, Ying-Chen& Lin, Hsueh-Yi& Su, Kang-Yi& Chen, Chien-Hsu& Yu, Yung-Lung& Lin, Chai-Ching…[et al.]. 2012. Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028664
Modern Language Association (MLA)
Yang, Ying-Chen…[et al.]. Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028664
American Medical Association (AMA)
Yang, Ying-Chen& Lin, Hsueh-Yi& Su, Kang-Yi& Chen, Chien-Hsu& Yu, Yung-Lung& Lin, Chai-Ching…[et al.]. Rutin, a Flavonoid That Is a Main Component of Saussurea involucrata, Attenuates the Senescence Effect in D-Galactose Aging Mouse Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028664
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028664