Inhibition of Neurotoxic Secretory Phospholipases A2 Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from Harpalyce brasiliana Benth
المؤلفون المشاركون
Rabello, Marcelo M.
Araújo, Renata M.
Silveira, Edilberto R.
Fagundes, Fábio H. R.
Diz-Filho, Eduardo B. S.
Buzzo, Simone C.
Soares, Veronica C. G.
Toyama, Daniela de O.
Hernandes, Marcelo Z.
Monteiro, Helena S. A.
Toyama, Marcos H.
Gaeta, Henrique Hessel
Ximenes, Rafael Matos
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Secretory phospholipases A2 (sPLA2) exert proinflammatory actions through lipid mediators.
These enzymes have been found to be elevated in many inflammatory disorders such as rheumatoid arthritis, sepsis, and atherosclerosis.
The aim of this study was to evaluate the effect of harpalycin 2 (Har2), an isoflavone isolated from Harpalyce brasiliana Benth., in the enzymatic, edematogenic, and myotoxic activities of sPLA2 from Bothrops pirajai, Crotalus durissus terrificus, Apis mellifera, and Naja naja venoms.
Har2 inhibits all sPLA2 tested.
PrTX-III (B.
pirajai venom) was inhibited at about 58.7%, Cdt F15 (C.
d.
terrificus venom) at 78.8%, Apis (from bee venom) at 87.7%, and Naja (N.
naja venom) at 88.1%.
Edema induced by exogenous sPLA2 administration performed in mice paws showed significant inhibition by Har2 at the initial step.
In addition, Har2 also inhibited the myotoxic activity of these sPLA2s.
In order to understand how Har2 interacts with these enzymes, docking calculations were made, indicating that the residues His48 and Asp49 in the active site of these enzymes interacted powerfully with Har2 through hydrogen bonds.
These data pointed to a possible anti-inflammatory activity of Har2 through sPLA2 inhibition.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ximenes, Rafael Matos& Rabello, Marcelo M.& Araújo, Renata M.& Silveira, Edilberto R.& Fagundes, Fábio H. R.& Diz-Filho, Eduardo B. S.…[et al.]. 2012. Inhibition of Neurotoxic Secretory Phospholipases A2 Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from Harpalyce brasiliana Benth. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028677
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ximenes, Rafael Matos…[et al.]. Inhibition of Neurotoxic Secretory Phospholipases A2 Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from Harpalyce brasiliana Benth. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028677
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ximenes, Rafael Matos& Rabello, Marcelo M.& Araújo, Renata M.& Silveira, Edilberto R.& Fagundes, Fábio H. R.& Diz-Filho, Eduardo B. S.…[et al.]. Inhibition of Neurotoxic Secretory Phospholipases A2 Enzymatic, Edematogenic, and Myotoxic Activities by Harpalycin 2, an Isoflavone Isolated from Harpalyce brasiliana Benth. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028677
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1028677
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر