Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze
المؤلفون المشاركون
Klaassen, E. M. M.
Kant, K. D. G. van de
Jöbsis, Q.
Høvig, S. T. P.
Schayck, C. P. van
Dompeling, E.
Rijkers, Ger T.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
A reliable asthma diagnosis is challenging in preschool wheezing children.
As inhaled corticosteroids (ICS) are more effective in asthmatics than in children with transient wheeze, an ICS response might be helpful in early asthma diagnosis.
Methods.
175 children (aged two–four years) with recurrent wheeze received 200 μg Beclomethasone extra-fine daily for eight weeks.
Changes in Exhaled Breath Condensate (EBC) biomarkers (pH, interleukin (IL)-1α, IL-2, IL-4, IL-5, IL-10, IFN-γ, sICAM, and CCL-11), Fractional exhaled Nitric Oxide (FeNO), airway resistance, and symptoms were assessed.
At six years of age a child was diagnosed as transient wheezer or asthmatic.
Adjusted logistic regression analysis was performed with multiple testing correction.
Results.
106 transient wheezers and 64 asthmatics were analysed at six years of age.
Neither changes in EBC biomarkers, nor FeNO, airway resistance, or symptoms during ICS trial at preschool age were related to asthma diagnosis at six years of age.
However, asthmatics had more airway symptoms before the start of the ICS trial than transient wheezers (P<0.01).
Discussion.
Although symptom score in preschool wheezing children at baseline was associated with asthma at six years of age, EBC biomarkers, airway resistance, or symptom response to ICS at preschool age could not predict asthma diagnosis at six years of age.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Klaassen, E. M. M.& Kant, K. D. G. van de& Jöbsis, Q.& Høvig, S. T. P.& Schayck, C. P. van& Rijkers, Ger T.…[et al.]. 2012. Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029372
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Klaassen, E. M. M.…[et al.]. Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1029372
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Klaassen, E. M. M.& Kant, K. D. G. van de& Jöbsis, Q.& Høvig, S. T. P.& Schayck, C. P. van& Rijkers, Ger T.…[et al.]. Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029372
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029372
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر