Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze
Joint Authors
Klaassen, E. M. M.
Kant, K. D. G. van de
Jöbsis, Q.
Høvig, S. T. P.
Schayck, C. P. van
Dompeling, E.
Rijkers, Ger T.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
A reliable asthma diagnosis is challenging in preschool wheezing children.
As inhaled corticosteroids (ICS) are more effective in asthmatics than in children with transient wheeze, an ICS response might be helpful in early asthma diagnosis.
Methods.
175 children (aged two–four years) with recurrent wheeze received 200 μg Beclomethasone extra-fine daily for eight weeks.
Changes in Exhaled Breath Condensate (EBC) biomarkers (pH, interleukin (IL)-1α, IL-2, IL-4, IL-5, IL-10, IFN-γ, sICAM, and CCL-11), Fractional exhaled Nitric Oxide (FeNO), airway resistance, and symptoms were assessed.
At six years of age a child was diagnosed as transient wheezer or asthmatic.
Adjusted logistic regression analysis was performed with multiple testing correction.
Results.
106 transient wheezers and 64 asthmatics were analysed at six years of age.
Neither changes in EBC biomarkers, nor FeNO, airway resistance, or symptoms during ICS trial at preschool age were related to asthma diagnosis at six years of age.
However, asthmatics had more airway symptoms before the start of the ICS trial than transient wheezers (P<0.01).
Discussion.
Although symptom score in preschool wheezing children at baseline was associated with asthma at six years of age, EBC biomarkers, airway resistance, or symptom response to ICS at preschool age could not predict asthma diagnosis at six years of age.
American Psychological Association (APA)
Klaassen, E. M. M.& Kant, K. D. G. van de& Jöbsis, Q.& Høvig, S. T. P.& Schayck, C. P. van& Rijkers, Ger T.…[et al.]. 2012. Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029372
Modern Language Association (MLA)
Klaassen, E. M. M.…[et al.]. Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze. Mediators of Inflammation No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1029372
American Medical Association (AMA)
Klaassen, E. M. M.& Kant, K. D. G. van de& Jöbsis, Q.& Høvig, S. T. P.& Schayck, C. P. van& Rijkers, Ger T.…[et al.]. Symptoms, but Not a Biomarker Response to Inhaled Corticosteroids, Predict Asthma in Preschool Children with Recurrent Wheeze. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1029372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029372