Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals
المؤلفون المشاركون
Quercioli, Alessandra
Montecucco, Fabrizio
Galan, Katia
Ratib, Osman
Roux-Lombard, Pascale
Pagano, Sabrina
Schindler, Thomas H.
Mach, François
Vuilleumier, N.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-07
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
We aimed at determining whether anti-apolipoprotein (apo) A-1 IgG levels are independent predictors of coronary artery calcification (CAC) and coronary endothelial dysfunction in obese and nonobese subjects without cardiovascular disease.
48 nonobese and 43 obese subjects were included.
CAC score was measured by thorax scanner and defined by an Agatston score > 0.
Coronary endothelial dysfunction was determined by measuring myocardial blood flow responses to cold pressor test (CPT) on PET/CT.
Serum anti-apoA-1 IgG levels were measured by ELISA.
Prevalence of coronary calcification was similar between the two study groups, but the prevalence of coronary endothelial dysfunction was higher in obese subjects.
Anti-apoA-1 IgG levels and positivity rate were higher in obese than in nonobese individuals.
CAC score was higher in anti-apoA-1 IgG positive subjects.
ROC analyses indicated that anti-apoA-1 IgG levels were significant predictors of CAC > 0, but not of coronary endothelial dysfunction with a negative predictive value of 94%.
Anti-apoA-1 IgG positivity was associated with a 17-fold independent increased risk of CAC > 0.
In conclusion, those preliminary results indicate that anti-apoA-1 IgG autoantibodies are raised in obese subjects and independently predict the presence of coronary calcification in this population but not the presence of coronary endothelial dysfunction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Quercioli, Alessandra& Montecucco, Fabrizio& Galan, Katia& Ratib, Osman& Roux-Lombard, Pascale& Pagano, Sabrina…[et al.]. 2012. Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029384
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Quercioli, Alessandra…[et al.]. Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals. Mediators of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1029384
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Quercioli, Alessandra& Montecucco, Fabrizio& Galan, Katia& Ratib, Osman& Roux-Lombard, Pascale& Pagano, Sabrina…[et al.]. Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029384
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029384
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر