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Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals
Joint Authors
Quercioli, Alessandra
Montecucco, Fabrizio
Galan, Katia
Ratib, Osman
Roux-Lombard, Pascale
Pagano, Sabrina
Schindler, Thomas H.
Mach, François
Vuilleumier, N.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-07
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
We aimed at determining whether anti-apolipoprotein (apo) A-1 IgG levels are independent predictors of coronary artery calcification (CAC) and coronary endothelial dysfunction in obese and nonobese subjects without cardiovascular disease.
48 nonobese and 43 obese subjects were included.
CAC score was measured by thorax scanner and defined by an Agatston score > 0.
Coronary endothelial dysfunction was determined by measuring myocardial blood flow responses to cold pressor test (CPT) on PET/CT.
Serum anti-apoA-1 IgG levels were measured by ELISA.
Prevalence of coronary calcification was similar between the two study groups, but the prevalence of coronary endothelial dysfunction was higher in obese subjects.
Anti-apoA-1 IgG levels and positivity rate were higher in obese than in nonobese individuals.
CAC score was higher in anti-apoA-1 IgG positive subjects.
ROC analyses indicated that anti-apoA-1 IgG levels were significant predictors of CAC > 0, but not of coronary endothelial dysfunction with a negative predictive value of 94%.
Anti-apoA-1 IgG positivity was associated with a 17-fold independent increased risk of CAC > 0.
In conclusion, those preliminary results indicate that anti-apoA-1 IgG autoantibodies are raised in obese subjects and independently predict the presence of coronary calcification in this population but not the presence of coronary endothelial dysfunction.
American Psychological Association (APA)
Quercioli, Alessandra& Montecucco, Fabrizio& Galan, Katia& Ratib, Osman& Roux-Lombard, Pascale& Pagano, Sabrina…[et al.]. 2012. Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029384
Modern Language Association (MLA)
Quercioli, Alessandra…[et al.]. Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals. Mediators of Inflammation No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1029384
American Medical Association (AMA)
Quercioli, Alessandra& Montecucco, Fabrizio& Galan, Katia& Ratib, Osman& Roux-Lombard, Pascale& Pagano, Sabrina…[et al.]. Anti-Apolipoprotein A-1 IgG Levels Predict Coronary Artery Calcification in Obese but Otherwise Healthy Individuals. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1029384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029384