The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses
المؤلفون المشاركون
Oh, Jueun
Yi, Young-Su
Byeon, Se Eun
Yoo, Byong Chul
Cho, Jae Youl
Hong, Sungyoul
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-11
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation.
Many studies have shown that Src plays multiple roles in macrophage-mediated innate immunity, such as phagocytosis, the production of inflammatory cytokines/mediators, and the induction of cellular migration, which strongly implies that Src plays a pivotal role in the functional activation of macrophages.
Macrophages are involved in a variety of immune responses and in inflammatory diseases including rheumatoid arthritis, atherosclerosis, diabetes, obesity, cancer, and osteoporosis.
Previous studies have suggested roles for Src in macrophage-mediated inflammatory responses; however, recently, new functions for Src have been reported, implying that Src functions in macrophage-mediated inflammatory responses that have not been described.
In this paper, we discuss recent studies regarding a number of these newly defined functions of Src in macrophage-mediated inflammatory responses.
Moreover, we discuss the feasibility of Src as a target for the development of new pharmaceutical drugs to treat macrophage-mediated inflammatory diseases.
We provide insights into recent reports regarding new functions for Src that are related to macrophage-related inflammatory responses and the development of novel Src inhibitors with strong immunosuppressive and anti-inflammatory properties, which could be applied to various macrophage-mediated inflammatory diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Byeon, Se Eun& Yi, Young-Su& Oh, Jueun& Yoo, Byong Chul& Hong, Sungyoul& Cho, Jae Youl. 2012. The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-1029411
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Byeon, Se Eun…[et al.]. The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-1029411
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Byeon, Se Eun& Yi, Young-Su& Oh, Jueun& Yoo, Byong Chul& Hong, Sungyoul& Cho, Jae Youl. The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-1029411
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1029411
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر