The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses
Joint Authors
Oh, Jueun
Yi, Young-Su
Byeon, Se Eun
Yoo, Byong Chul
Cho, Jae Youl
Hong, Sungyoul
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-11
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and proliferation.
Many studies have shown that Src plays multiple roles in macrophage-mediated innate immunity, such as phagocytosis, the production of inflammatory cytokines/mediators, and the induction of cellular migration, which strongly implies that Src plays a pivotal role in the functional activation of macrophages.
Macrophages are involved in a variety of immune responses and in inflammatory diseases including rheumatoid arthritis, atherosclerosis, diabetes, obesity, cancer, and osteoporosis.
Previous studies have suggested roles for Src in macrophage-mediated inflammatory responses; however, recently, new functions for Src have been reported, implying that Src functions in macrophage-mediated inflammatory responses that have not been described.
In this paper, we discuss recent studies regarding a number of these newly defined functions of Src in macrophage-mediated inflammatory responses.
Moreover, we discuss the feasibility of Src as a target for the development of new pharmaceutical drugs to treat macrophage-mediated inflammatory diseases.
We provide insights into recent reports regarding new functions for Src that are related to macrophage-related inflammatory responses and the development of novel Src inhibitors with strong immunosuppressive and anti-inflammatory properties, which could be applied to various macrophage-mediated inflammatory diseases.
American Psychological Association (APA)
Byeon, Se Eun& Yi, Young-Su& Oh, Jueun& Yoo, Byong Chul& Hong, Sungyoul& Cho, Jae Youl. 2012. The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-1029411
Modern Language Association (MLA)
Byeon, Se Eun…[et al.]. The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-1029411
American Medical Association (AMA)
Byeon, Se Eun& Yi, Young-Su& Oh, Jueun& Yoo, Byong Chul& Hong, Sungyoul& Cho, Jae Youl. The Role of Src Kinase in Macrophage-Mediated Inflammatory Responses. Mediators of Inflammation. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-1029411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1029411