Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies
المؤلفون المشاركون
Dinarvand, Rassoul
Saremi, Shahrooz
Kebriaeezadeh, Abbas
Ostad, Seyed Nasser
Atyabi, Fatemeh
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-18
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The aim of this study was to evaluate a nanoparticulate system with mucoadhesion properties composed of a core of polymethyl methacrylate surrounded by a shell of thiolated chitosan (Ch-GSH-pMMA) for enhancing oral bioavailability of docetaxel (DTX), an anticancer drug.
DTX-loaded nanoparticles were prepared by emulsion polymerization method using cerium ammonium nitrate as an initiator.
Physicochemical properties of the nanoparticles such as particle size, size distribution, morphology, drug loading, and entrapment efficiency were characterized.
The pharmacokinetic study was carried out in vivo using wistar rats.
The half-life of DTX-loaded NPs was about 9 times longer than oral DTX used as positive control.
The oral bioavailability of DTX was increased to 68.9% for DTX-loaded nanoparticles compared to 6.5% for positive control.
The nanoparticles showed stronger effect on the reduction of the transepithelial electrical resistance (TEER) of Caco-2 cell monolayer by opening the tight junctions.
According to apparent permeability coefficient (Papp) results, the DTX-loaded NPs showed more specific permeation across the Caco-2 cell monolayer in comparison to the DTX.
In conclusion, the nanoparticles prepared in this study showed promising results for the development of an oral drug delivery system for anticancer drugs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saremi, Shahrooz& Dinarvand, Rassoul& Kebriaeezadeh, Abbas& Ostad, Seyed Nasser& Atyabi, Fatemeh. 2013. Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030123
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saremi, Shahrooz…[et al.]. Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030123
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saremi, Shahrooz& Dinarvand, Rassoul& Kebriaeezadeh, Abbas& Ostad, Seyed Nasser& Atyabi, Fatemeh. Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030123
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030123
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر