Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies
Joint Authors
Dinarvand, Rassoul
Saremi, Shahrooz
Kebriaeezadeh, Abbas
Ostad, Seyed Nasser
Atyabi, Fatemeh
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The aim of this study was to evaluate a nanoparticulate system with mucoadhesion properties composed of a core of polymethyl methacrylate surrounded by a shell of thiolated chitosan (Ch-GSH-pMMA) for enhancing oral bioavailability of docetaxel (DTX), an anticancer drug.
DTX-loaded nanoparticles were prepared by emulsion polymerization method using cerium ammonium nitrate as an initiator.
Physicochemical properties of the nanoparticles such as particle size, size distribution, morphology, drug loading, and entrapment efficiency were characterized.
The pharmacokinetic study was carried out in vivo using wistar rats.
The half-life of DTX-loaded NPs was about 9 times longer than oral DTX used as positive control.
The oral bioavailability of DTX was increased to 68.9% for DTX-loaded nanoparticles compared to 6.5% for positive control.
The nanoparticles showed stronger effect on the reduction of the transepithelial electrical resistance (TEER) of Caco-2 cell monolayer by opening the tight junctions.
According to apparent permeability coefficient (Papp) results, the DTX-loaded NPs showed more specific permeation across the Caco-2 cell monolayer in comparison to the DTX.
In conclusion, the nanoparticles prepared in this study showed promising results for the development of an oral drug delivery system for anticancer drugs.
American Psychological Association (APA)
Saremi, Shahrooz& Dinarvand, Rassoul& Kebriaeezadeh, Abbas& Ostad, Seyed Nasser& Atyabi, Fatemeh. 2013. Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030123
Modern Language Association (MLA)
Saremi, Shahrooz…[et al.]. Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030123
American Medical Association (AMA)
Saremi, Shahrooz& Dinarvand, Rassoul& Kebriaeezadeh, Abbas& Ostad, Seyed Nasser& Atyabi, Fatemeh. Enhanced Oral Delivery of Docetaxel Using Thiolated Chitosan Nanoparticles: Preparation, In Vitro and In Vivo Studies. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030123
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030123