Difference of Morphology and Immunophenotype between Central and Peripheral Squamous Cell Carcinomas of the Lung

المؤلفون المشاركون

Sano, Hisao
Egashira, Ryoko
Tabata, Kazuhiro
Tanaka, Tomonori
Kashima, Yukio
Hori, Takashi
Nunomura, Sayuri
Fukuoka, Junya
Nakayama, Toshiyuki
Hayashi, Tomayoshi

المصدر

BioMed Research International

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-08-28

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

Recent agents, that is, pemetrexed and bevacizumab, have shown reproductive negative association between squamous histology.

According to these agents' effectiveness, ruling out of the squamous histology is a significant issue for surgical pathologists.

Several articles have proposed the distinction of peripheral type from central type of squamous cell carcinoma (SqCC) due to its similarity to adenocarcinoma, although little evidence to support the difference between these two types was published.

In this study, we compared the clinicopathologic findings of central and peripheral pulmonary SqCCs.

Material and Methods.

15 central and 35 peripheral types of SqCC from 2005 to 2010 were examined.

Twelve morphological features were scored based on their intensity in the original H&E slides, and then, tissue microarray holding triplicated cores from 43 cases was immunohistochemically examined for cytokeratin (CK)7, CK14, TTF-1, Napsin A, p63, CK34βE12, CK5/6, and p53.

Result.

Most of the histological findings did not separate central and peripheral SqCCs; only the presence of emphysema, interstitial fibrosis, and entrapped pneumocytes inside the tumor showed statistic predominance in peripheral SqCC.

This is the first immunophenotypic research in the central and peripheral types of SqCC.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Hayashi, Tomayoshi& Sano, Hisao& Egashira, Ryoko& Tabata, Kazuhiro& Tanaka, Tomonori& Nakayama, Toshiyuki…[et al.]. 2013. Difference of Morphology and Immunophenotype between Central and Peripheral Squamous Cell Carcinomas of the Lung. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030141

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Hayashi, Tomayoshi…[et al.]. Difference of Morphology and Immunophenotype between Central and Peripheral Squamous Cell Carcinomas of the Lung. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030141

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Hayashi, Tomayoshi& Sano, Hisao& Egashira, Ryoko& Tabata, Kazuhiro& Tanaka, Tomonori& Nakayama, Toshiyuki…[et al.]. Difference of Morphology and Immunophenotype between Central and Peripheral Squamous Cell Carcinomas of the Lung. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030141

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1030141