Difference of Morphology and Immunophenotype between Central and Peripheral Squamous Cell Carcinomas of the Lung
Joint Authors
Sano, Hisao
Egashira, Ryoko
Tabata, Kazuhiro
Tanaka, Tomonori
Kashima, Yukio
Hori, Takashi
Nunomura, Sayuri
Fukuoka, Junya
Nakayama, Toshiyuki
Hayashi, Tomayoshi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Recent agents, that is, pemetrexed and bevacizumab, have shown reproductive negative association between squamous histology.
According to these agents' effectiveness, ruling out of the squamous histology is a significant issue for surgical pathologists.
Several articles have proposed the distinction of peripheral type from central type of squamous cell carcinoma (SqCC) due to its similarity to adenocarcinoma, although little evidence to support the difference between these two types was published.
In this study, we compared the clinicopathologic findings of central and peripheral pulmonary SqCCs.
Material and Methods.
15 central and 35 peripheral types of SqCC from 2005 to 2010 were examined.
Twelve morphological features were scored based on their intensity in the original H&E slides, and then, tissue microarray holding triplicated cores from 43 cases was immunohistochemically examined for cytokeratin (CK)7, CK14, TTF-1, Napsin A, p63, CK34βE12, CK5/6, and p53.
Result.
Most of the histological findings did not separate central and peripheral SqCCs; only the presence of emphysema, interstitial fibrosis, and entrapped pneumocytes inside the tumor showed statistic predominance in peripheral SqCC.
This is the first immunophenotypic research in the central and peripheral types of SqCC.
American Psychological Association (APA)
Hayashi, Tomayoshi& Sano, Hisao& Egashira, Ryoko& Tabata, Kazuhiro& Tanaka, Tomonori& Nakayama, Toshiyuki…[et al.]. 2013. Difference of Morphology and Immunophenotype between Central and Peripheral Squamous Cell Carcinomas of the Lung. BioMed Research International،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030141
Modern Language Association (MLA)
Hayashi, Tomayoshi…[et al.]. Difference of Morphology and Immunophenotype between Central and Peripheral Squamous Cell Carcinomas of the Lung. BioMed Research International No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-1030141
American Medical Association (AMA)
Hayashi, Tomayoshi& Sano, Hisao& Egashira, Ryoko& Tabata, Kazuhiro& Tanaka, Tomonori& Nakayama, Toshiyuki…[et al.]. Difference of Morphology and Immunophenotype between Central and Peripheral Squamous Cell Carcinomas of the Lung. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-1030141
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030141