A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis
المؤلفون المشاركون
Martel-Pelletier, Johanne
Pelletier, Jean-Pierre
Moreau, Maxim
Lussier, Bertrand
Troncy, Eric
d’Anjou, Marc-André
Blond, Laurent
del Castillo, Jérôme R. E.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
For many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA).
Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning.
The usefulness of noninvasive complementary outcome measures, such as gait analysis for the limb function and magnetic resonance imaging for structural changes, was demonstrated in this model.
Relationships were established between the functional impairment and the severity of structural changes including the measurement of cartilage thinning.
In the dog model of naturally occurring OA, excellent test-retest reliability was denoted for the measurement of the limb function.
A criterion to identify clinically meaningful responders to therapy was determined for privately owned dogs undergoing clinical trials.
In addition, the recording of accelerometer-based duration of locomotor activity showed strong and complementary agreement with the biomechanical limb function.
The translation potential of these models to the human OA condition is underlined.
A preclinical testing protocol which combines the dog model of experimental OA induced by cranial cruciate ligament transection and the Dog model of naturally occurring OA offers the opportunity to further investigate the structural and functional benefits of disease-modifying strategies.
Ultimately, a better prediction of outcomes for human clinical trials would be brought.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moreau, Maxim& Pelletier, Jean-Pierre& Lussier, Bertrand& d’Anjou, Marc-André& Blond, Laurent& Martel-Pelletier, Johanne…[et al.]. 2013. A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030162
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moreau, Maxim…[et al.]. A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030162
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moreau, Maxim& Pelletier, Jean-Pierre& Lussier, Bertrand& d’Anjou, Marc-André& Blond, Laurent& Martel-Pelletier, Johanne…[et al.]. A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030162
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030162
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر