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A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis
Joint Authors
Martel-Pelletier, Johanne
Pelletier, Jean-Pierre
Moreau, Maxim
Lussier, Bertrand
Troncy, Eric
d’Anjou, Marc-André
Blond, Laurent
del Castillo, Jérôme R. E.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
For many years Canis familiaris, the domestic dog, has drawn particular interest as a model of osteoarthritis (OA).
Here, we optimized the dog model of experimental OA induced by cranial cruciate ligament sectioning.
The usefulness of noninvasive complementary outcome measures, such as gait analysis for the limb function and magnetic resonance imaging for structural changes, was demonstrated in this model.
Relationships were established between the functional impairment and the severity of structural changes including the measurement of cartilage thinning.
In the dog model of naturally occurring OA, excellent test-retest reliability was denoted for the measurement of the limb function.
A criterion to identify clinically meaningful responders to therapy was determined for privately owned dogs undergoing clinical trials.
In addition, the recording of accelerometer-based duration of locomotor activity showed strong and complementary agreement with the biomechanical limb function.
The translation potential of these models to the human OA condition is underlined.
A preclinical testing protocol which combines the dog model of experimental OA induced by cranial cruciate ligament transection and the Dog model of naturally occurring OA offers the opportunity to further investigate the structural and functional benefits of disease-modifying strategies.
Ultimately, a better prediction of outcomes for human clinical trials would be brought.
American Psychological Association (APA)
Moreau, Maxim& Pelletier, Jean-Pierre& Lussier, Bertrand& d’Anjou, Marc-André& Blond, Laurent& Martel-Pelletier, Johanne…[et al.]. 2013. A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030162
Modern Language Association (MLA)
Moreau, Maxim…[et al.]. A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030162
American Medical Association (AMA)
Moreau, Maxim& Pelletier, Jean-Pierre& Lussier, Bertrand& d’Anjou, Marc-André& Blond, Laurent& Martel-Pelletier, Johanne…[et al.]. A Posteriori Comparison of Natural and Surgical Destabilization Models of Canine Osteoarthritis. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030162