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Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(ε-caprolactone), and Itaconic Acid
المؤلفون المشاركون
Qian, Zhiyong
Luo, Feng
Xu, Xu
Tan, Liwei
Song, Jia
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
A kind of chemically cross-linked pH-sensitive hydrogels based on methoxyl poly(ethylene glycol)-poly(caprolactone)-acryloyl chloride (MPEG-PCL-AC, PECA), poly(ethylene glycol) methyl ether methacrylate (MPEGMA, MEG), N,N-methylenebisacrylamide (BIS), and itaconic acid (IA) were prepared without using any organic solvent by heat-initiated free radical method.
The obtained macromonomers and hydrogels were characterized by 1H NMR and FT-IR, respectively.
Morphology study of hydrogels was also investigated in this paper, and it showed that the hydrogels had good pH-sensitivity.
The acute toxicity test and histopathological study were conducted in BALB/c mice.
The results indicated that the maximum tolerance dose of the hydrogel was higher than 10000 mg/kg body weight.
No morality or signs of toxicity were observed during the whole 7-day observation period.
Compared to the control groups, there were no important adverse effects in the variables of hematology routine test and serum chemistry analysis both in male or female treatment group.
Histopathological study also did not show any significant lesions, including heart, liver, lung, spleen, kidney, stomach, intestine, and testis.
All the results demonstrated that this hydrogel was nontoxic after gavage.
Thus, the hydrogel might be the biocompatible potential candidate for oral drug delivery system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tan, Liwei& Xu, Xu& Song, Jia& Luo, Feng& Qian, Zhiyong. 2013. Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(ε-caprolactone), and Itaconic Acid. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030216
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tan, Liwei…[et al.]. Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(ε-caprolactone), and Itaconic Acid. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030216
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tan, Liwei& Xu, Xu& Song, Jia& Luo, Feng& Qian, Zhiyong. Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(ε-caprolactone), and Itaconic Acid. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030216
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030216
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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