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Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(ε-caprolactone), and Itaconic Acid
Joint Authors
Qian, Zhiyong
Luo, Feng
Xu, Xu
Tan, Liwei
Song, Jia
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A kind of chemically cross-linked pH-sensitive hydrogels based on methoxyl poly(ethylene glycol)-poly(caprolactone)-acryloyl chloride (MPEG-PCL-AC, PECA), poly(ethylene glycol) methyl ether methacrylate (MPEGMA, MEG), N,N-methylenebisacrylamide (BIS), and itaconic acid (IA) were prepared without using any organic solvent by heat-initiated free radical method.
The obtained macromonomers and hydrogels were characterized by 1H NMR and FT-IR, respectively.
Morphology study of hydrogels was also investigated in this paper, and it showed that the hydrogels had good pH-sensitivity.
The acute toxicity test and histopathological study were conducted in BALB/c mice.
The results indicated that the maximum tolerance dose of the hydrogel was higher than 10000 mg/kg body weight.
No morality or signs of toxicity were observed during the whole 7-day observation period.
Compared to the control groups, there were no important adverse effects in the variables of hematology routine test and serum chemistry analysis both in male or female treatment group.
Histopathological study also did not show any significant lesions, including heart, liver, lung, spleen, kidney, stomach, intestine, and testis.
All the results demonstrated that this hydrogel was nontoxic after gavage.
Thus, the hydrogel might be the biocompatible potential candidate for oral drug delivery system.
American Psychological Association (APA)
Tan, Liwei& Xu, Xu& Song, Jia& Luo, Feng& Qian, Zhiyong. 2013. Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(ε-caprolactone), and Itaconic Acid. BioMed Research International،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030216
Modern Language Association (MLA)
Tan, Liwei…[et al.]. Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(ε-caprolactone), and Itaconic Acid. BioMed Research International No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-1030216
American Medical Association (AMA)
Tan, Liwei& Xu, Xu& Song, Jia& Luo, Feng& Qian, Zhiyong. Synthesis, Characterization, and Acute Oral Toxicity Evaluation of pH-Sensitive Hydrogel Based on MPEG, Poly(ε-caprolactone), and Itaconic Acid. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-1030216
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030216