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Helical Tomotherapy for Inoperable Breast Cancer: A New Promising Tool
المؤلفون المشاركون
Chira, Ciprian
Kirova, Youlia M.
Liem, Xavier
Campana, François
Peurien, Dominique
Amessis, Malika
Fournier-Bidoz, Nathalie
Dendale, Rémi
Bey, Pierre
Fourquet, Alain
Pierga, Jean-Yves
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-02
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
We investigated the feasibility of helical tomotherapy (HT) for inoperable large breast tumors, after failing to achieve adequate treatment planning with conformal radiation techniques.
Material and Methods.
Five consecutive patients with locally advanced breast cancer (LABC) were treated by preoperative HT.
All patients received up-front chemotherapy before HT.
Irradiated volumes included breast and nodal areas (45–50 Gy) in 4 patients.
One patient received a simultaneous integrated boost (55 Gy) to gross tumor volume (GTV) without lymph node irradiation.
Acute toxicity was assessed with Common Toxicity Criteria for Adverse Events v.4.
Patients were evaluated for surgery at the end of treatment.
Results.
Patients were staged IIB to IIIC (according to the AJCC staging system 2010).
HT was associated in 4 patients with concomitant chemotherapy (5-fluorouracil and vinorelbine).
Two patients were scored with grade 3 skin toxicity (had not completed HT) and one with grade 3 febrile neutropenia.
One patient stopped HT with grade 2 skin toxicity.
All patients were able to undergo mastectomy at a median interval of 43 days (31–52) from HT.
Pathological partial response was seen in all patients.
Conclusions.
HT is feasible with acceptable toxicity profiles, potentially increased by chemotherapy.
These preliminary results prompt us to consider a phase II study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chira, Ciprian& Kirova, Youlia M.& Liem, Xavier& Campana, François& Peurien, Dominique& Amessis, Malika…[et al.]. 2013. Helical Tomotherapy for Inoperable Breast Cancer: A New Promising Tool. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030258
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chira, Ciprian…[et al.]. Helical Tomotherapy for Inoperable Breast Cancer: A New Promising Tool. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030258
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chira, Ciprian& Kirova, Youlia M.& Liem, Xavier& Campana, François& Peurien, Dominique& Amessis, Malika…[et al.]. Helical Tomotherapy for Inoperable Breast Cancer: A New Promising Tool. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030258
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030258
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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