Helical Tomotherapy for Inoperable Breast Cancer: A New Promising Tool
Joint Authors
Chira, Ciprian
Kirova, Youlia M.
Liem, Xavier
Campana, François
Peurien, Dominique
Amessis, Malika
Fournier-Bidoz, Nathalie
Dendale, Rémi
Bey, Pierre
Fourquet, Alain
Pierga, Jean-Yves
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
We investigated the feasibility of helical tomotherapy (HT) for inoperable large breast tumors, after failing to achieve adequate treatment planning with conformal radiation techniques.
Material and Methods.
Five consecutive patients with locally advanced breast cancer (LABC) were treated by preoperative HT.
All patients received up-front chemotherapy before HT.
Irradiated volumes included breast and nodal areas (45–50 Gy) in 4 patients.
One patient received a simultaneous integrated boost (55 Gy) to gross tumor volume (GTV) without lymph node irradiation.
Acute toxicity was assessed with Common Toxicity Criteria for Adverse Events v.4.
Patients were evaluated for surgery at the end of treatment.
Results.
Patients were staged IIB to IIIC (according to the AJCC staging system 2010).
HT was associated in 4 patients with concomitant chemotherapy (5-fluorouracil and vinorelbine).
Two patients were scored with grade 3 skin toxicity (had not completed HT) and one with grade 3 febrile neutropenia.
One patient stopped HT with grade 2 skin toxicity.
All patients were able to undergo mastectomy at a median interval of 43 days (31–52) from HT.
Pathological partial response was seen in all patients.
Conclusions.
HT is feasible with acceptable toxicity profiles, potentially increased by chemotherapy.
These preliminary results prompt us to consider a phase II study.
American Psychological Association (APA)
Chira, Ciprian& Kirova, Youlia M.& Liem, Xavier& Campana, François& Peurien, Dominique& Amessis, Malika…[et al.]. 2013. Helical Tomotherapy for Inoperable Breast Cancer: A New Promising Tool. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030258
Modern Language Association (MLA)
Chira, Ciprian…[et al.]. Helical Tomotherapy for Inoperable Breast Cancer: A New Promising Tool. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030258
American Medical Association (AMA)
Chira, Ciprian& Kirova, Youlia M.& Liem, Xavier& Campana, François& Peurien, Dominique& Amessis, Malika…[et al.]. Helical Tomotherapy for Inoperable Breast Cancer: A New Promising Tool. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030258