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Antivenom Effects of 1,2,3-Triazoles against Bothrops jararaca and Lachesis muta Snakes
المؤلفون المشاركون
Domingos, Thaisa F. S.
Carvalho, Carla
Campos, Vinícius R.
Jordão, Alessandro K.
Cunha, Anna C.
Ferreira, Vitor F.
de Souza, Maria Cecília B. V.
Sanchez, Eladio F.
Moura, Laura A.
Fuly, André Lopes
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Snake venoms are complex mixtures of proteins of both enzymes and nonenzymes, which are responsible for producing several biological effects.
Human envenomation by snake bites particularly those of the viperid family induces a complex pathophysiological picture characterized by spectacular changes in hemostasis and frequently hemorrhage is also seen.
The present work reports the ability of six of a series of 1,2,3-triazole derivatives to inhibit some pharmacological effects caused by the venoms of Bothrops jararaca and Lachesis muta.
In vitro assays showed that these compounds were impaired in a concentration-dependent manner, the fibrinogen or plasma clotting, hemolysis, and proteolysis produced by both venoms.
Moreover, these compounds inhibited biological effects in vivo as well.
Mice treated with these compounds were fully protected from hemorrhagic lesions caused by such venoms.
But, only the B.
jararaca edema-inducing activity was neutralized by the triazoles.
So the inhibitory effect of triazoles derivatives against some in vitro and in vivo biological assays of snake venoms points to promising aspects that may indicate them as molecular models to improve the production of effective antivenom or to complement antivenom neutralization, especially the local pathological effects, which are partially neutralized by antivenoms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Domingos, Thaisa F. S.& Moura, Laura A.& Carvalho, Carla& Campos, Vinícius R.& Jordão, Alessandro K.& Cunha, Anna C.…[et al.]. 2013. Antivenom Effects of 1,2,3-Triazoles against Bothrops jararaca and Lachesis muta Snakes. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030316
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Domingos, Thaisa F. S.…[et al.]. Antivenom Effects of 1,2,3-Triazoles against Bothrops jararaca and Lachesis muta Snakes. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030316
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Domingos, Thaisa F. S.& Moura, Laura A.& Carvalho, Carla& Campos, Vinícius R.& Jordão, Alessandro K.& Cunha, Anna C.…[et al.]. Antivenom Effects of 1,2,3-Triazoles against Bothrops jararaca and Lachesis muta Snakes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030316
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030316
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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