Antivenom Effects of 1,2,3-Triazoles against Bothrops jararaca and Lachesis muta Snakes
Joint Authors
Domingos, Thaisa F. S.
Carvalho, Carla
Campos, Vinícius R.
Jordão, Alessandro K.
Cunha, Anna C.
Ferreira, Vitor F.
de Souza, Maria Cecília B. V.
Sanchez, Eladio F.
Moura, Laura A.
Fuly, André Lopes
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-22
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Snake venoms are complex mixtures of proteins of both enzymes and nonenzymes, which are responsible for producing several biological effects.
Human envenomation by snake bites particularly those of the viperid family induces a complex pathophysiological picture characterized by spectacular changes in hemostasis and frequently hemorrhage is also seen.
The present work reports the ability of six of a series of 1,2,3-triazole derivatives to inhibit some pharmacological effects caused by the venoms of Bothrops jararaca and Lachesis muta.
In vitro assays showed that these compounds were impaired in a concentration-dependent manner, the fibrinogen or plasma clotting, hemolysis, and proteolysis produced by both venoms.
Moreover, these compounds inhibited biological effects in vivo as well.
Mice treated with these compounds were fully protected from hemorrhagic lesions caused by such venoms.
But, only the B.
jararaca edema-inducing activity was neutralized by the triazoles.
So the inhibitory effect of triazoles derivatives against some in vitro and in vivo biological assays of snake venoms points to promising aspects that may indicate them as molecular models to improve the production of effective antivenom or to complement antivenom neutralization, especially the local pathological effects, which are partially neutralized by antivenoms.
American Psychological Association (APA)
Domingos, Thaisa F. S.& Moura, Laura A.& Carvalho, Carla& Campos, Vinícius R.& Jordão, Alessandro K.& Cunha, Anna C.…[et al.]. 2013. Antivenom Effects of 1,2,3-Triazoles against Bothrops jararaca and Lachesis muta Snakes. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030316
Modern Language Association (MLA)
Domingos, Thaisa F. S.…[et al.]. Antivenom Effects of 1,2,3-Triazoles against Bothrops jararaca and Lachesis muta Snakes. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030316
American Medical Association (AMA)
Domingos, Thaisa F. S.& Moura, Laura A.& Carvalho, Carla& Campos, Vinícius R.& Jordão, Alessandro K.& Cunha, Anna C.…[et al.]. Antivenom Effects of 1,2,3-Triazoles against Bothrops jararaca and Lachesis muta Snakes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030316