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Acetylcholinesterase as a Biomarker in Environmental and Occupational Medicine: New Insights and Future Perspectives
المؤلفون المشاركون
Caricato, Roberto
Giordano, Maria Elena
Lionetto, M. G.
Calisi, A.
Schettino, T.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-10
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Acetylcholinesterase (AChE) is a key enzyme in the nervous system.
It terminates nerve impulses by catalysing the hydrolysis of neurotransmitter acetylcholine.
As a specific molecular target of organophosphate and carbamate pesticides, acetylcholinesterase activity and its inhibition has been early recognized to be a human biological marker of pesticide poisoning.
Measurement of AChE inhibition has been increasingly used in the last two decades as a biomarker of effect on nervous system following exposure to organophosphate and carbamate pesticides in occupational and environmental medicine.
The success of this biomarker arises from the fact that it meets a number of characteristics necessary for the successful application of a biological response as biomarker in human biomonitoring: the response is easy to measure, it shows a dose-dependent behavior to pollutant exposure, it is sensitive, and it exhibits a link to health adverse effects.
The aim of this work is to review and discuss the recent findings about acetylcholinesterase, including its sensitivity to other pollutants and the expression of different splice variants.
These insights open new perspective for the future use of this biomarker in environmental and occupational human health monitoring.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lionetto, M. G.& Caricato, Roberto& Calisi, A.& Giordano, Maria Elena& Schettino, T.. 2013. Acetylcholinesterase as a Biomarker in Environmental and Occupational Medicine: New Insights and Future Perspectives. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030386
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Caricato, Roberto…[et al.]. Acetylcholinesterase as a Biomarker in Environmental and Occupational Medicine: New Insights and Future Perspectives. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030386
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lionetto, M. G.& Caricato, Roberto& Calisi, A.& Giordano, Maria Elena& Schettino, T.. Acetylcholinesterase as a Biomarker in Environmental and Occupational Medicine: New Insights and Future Perspectives. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030386
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030386
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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