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Acetylcholinesterase as a Biomarker in Environmental and Occupational Medicine: New Insights and Future Perspectives
Joint Authors
Caricato, Roberto
Giordano, Maria Elena
Lionetto, M. G.
Calisi, A.
Schettino, T.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Acetylcholinesterase (AChE) is a key enzyme in the nervous system.
It terminates nerve impulses by catalysing the hydrolysis of neurotransmitter acetylcholine.
As a specific molecular target of organophosphate and carbamate pesticides, acetylcholinesterase activity and its inhibition has been early recognized to be a human biological marker of pesticide poisoning.
Measurement of AChE inhibition has been increasingly used in the last two decades as a biomarker of effect on nervous system following exposure to organophosphate and carbamate pesticides in occupational and environmental medicine.
The success of this biomarker arises from the fact that it meets a number of characteristics necessary for the successful application of a biological response as biomarker in human biomonitoring: the response is easy to measure, it shows a dose-dependent behavior to pollutant exposure, it is sensitive, and it exhibits a link to health adverse effects.
The aim of this work is to review and discuss the recent findings about acetylcholinesterase, including its sensitivity to other pollutants and the expression of different splice variants.
These insights open new perspective for the future use of this biomarker in environmental and occupational human health monitoring.
American Psychological Association (APA)
Lionetto, M. G.& Caricato, Roberto& Calisi, A.& Giordano, Maria Elena& Schettino, T.. 2013. Acetylcholinesterase as a Biomarker in Environmental and Occupational Medicine: New Insights and Future Perspectives. BioMed Research International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030386
Modern Language Association (MLA)
Caricato, Roberto…[et al.]. Acetylcholinesterase as a Biomarker in Environmental and Occupational Medicine: New Insights and Future Perspectives. BioMed Research International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-1030386
American Medical Association (AMA)
Lionetto, M. G.& Caricato, Roberto& Calisi, A.& Giordano, Maria Elena& Schettino, T.. Acetylcholinesterase as a Biomarker in Environmental and Occupational Medicine: New Insights and Future Perspectives. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-1030386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030386