Monocyte Locomotion Inhibitory Factor Produced by E. histolytica Improves Motor Recovery and Develops Neuroprotection after Traumatic Injury to the Spinal Cord
المؤلفون المشاركون
Blanco-Favela, Francisco
Bermeo, Gabriela
Ibarra, Antonio
García, Elisa
Flores-Romero, Adrian
Rico-Rosillo, Guadalupe
Marroquín, Rubén
Mestre, Humberto
Flores, Carmina
Silva-García, Raúl
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Monocyte locomotion inhibitory factor (MLIF) is a pentapeptide produced by Entamoeba histolytica that has a potent anti-inflammatory effect.
Either MLIF or phosphate buffered saline (PBS) was administered directly onto the spinal cord (SC) immediately after injury.
Motor recovery was evaluated.
We also analyzed neuroprotection by quantifying the number of surviving ventral horn motor neurons and the persistence of rubrospinal tract neurons.
To evaluate the mechanism through which MLIF improved the outcome of SC injury, we quantified the expression of inducible nitric oxide synthase (iNOS), interleukin-10 (IL-10), and transforming growth factor-β (TGF-β) genes at the site of injury.
Finally, the levels of nitric oxide and of lipid peroxidation were also determined in peripheral blood.
Results showed that MLIF improved the rate of motor recovery and this correlated with an increased survival of ventral horn and rubrospinal neurons.
These beneficial effects were in turn associated with a reduction in iNOS gene products and a significant upregulation of IL-10 and TGF-β expression.
In the same way, MLIF reduced the concentration of nitric oxide and the levels of lipid peroxidation in systemic circulation.
The present results demonstrate for the first time the neuroprotective effects endowed by MLIF after SC injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bermeo, Gabriela& Ibarra, Antonio& García, Elisa& Flores-Romero, Adrian& Rico-Rosillo, Guadalupe& Marroquín, Rubén…[et al.]. 2013. Monocyte Locomotion Inhibitory Factor Produced by E. histolytica Improves Motor Recovery and Develops Neuroprotection after Traumatic Injury to the Spinal Cord. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030412
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bermeo, Gabriela…[et al.]. Monocyte Locomotion Inhibitory Factor Produced by E. histolytica Improves Motor Recovery and Develops Neuroprotection after Traumatic Injury to the Spinal Cord. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030412
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bermeo, Gabriela& Ibarra, Antonio& García, Elisa& Flores-Romero, Adrian& Rico-Rosillo, Guadalupe& Marroquín, Rubén…[et al.]. Monocyte Locomotion Inhibitory Factor Produced by E. histolytica Improves Motor Recovery and Develops Neuroprotection after Traumatic Injury to the Spinal Cord. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030412
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030412
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر