Monocyte Locomotion Inhibitory Factor Produced by E. histolytica Improves Motor Recovery and Develops Neuroprotection after Traumatic Injury to the Spinal Cord
Joint Authors
Blanco-Favela, Francisco
Bermeo, Gabriela
Ibarra, Antonio
García, Elisa
Flores-Romero, Adrian
Rico-Rosillo, Guadalupe
Marroquín, Rubén
Mestre, Humberto
Flores, Carmina
Silva-García, Raúl
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-03
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Monocyte locomotion inhibitory factor (MLIF) is a pentapeptide produced by Entamoeba histolytica that has a potent anti-inflammatory effect.
Either MLIF or phosphate buffered saline (PBS) was administered directly onto the spinal cord (SC) immediately after injury.
Motor recovery was evaluated.
We also analyzed neuroprotection by quantifying the number of surviving ventral horn motor neurons and the persistence of rubrospinal tract neurons.
To evaluate the mechanism through which MLIF improved the outcome of SC injury, we quantified the expression of inducible nitric oxide synthase (iNOS), interleukin-10 (IL-10), and transforming growth factor-β (TGF-β) genes at the site of injury.
Finally, the levels of nitric oxide and of lipid peroxidation were also determined in peripheral blood.
Results showed that MLIF improved the rate of motor recovery and this correlated with an increased survival of ventral horn and rubrospinal neurons.
These beneficial effects were in turn associated with a reduction in iNOS gene products and a significant upregulation of IL-10 and TGF-β expression.
In the same way, MLIF reduced the concentration of nitric oxide and the levels of lipid peroxidation in systemic circulation.
The present results demonstrate for the first time the neuroprotective effects endowed by MLIF after SC injury.
American Psychological Association (APA)
Bermeo, Gabriela& Ibarra, Antonio& García, Elisa& Flores-Romero, Adrian& Rico-Rosillo, Guadalupe& Marroquín, Rubén…[et al.]. 2013. Monocyte Locomotion Inhibitory Factor Produced by E. histolytica Improves Motor Recovery and Develops Neuroprotection after Traumatic Injury to the Spinal Cord. BioMed Research International،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030412
Modern Language Association (MLA)
Bermeo, Gabriela…[et al.]. Monocyte Locomotion Inhibitory Factor Produced by E. histolytica Improves Motor Recovery and Develops Neuroprotection after Traumatic Injury to the Spinal Cord. BioMed Research International No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-1030412
American Medical Association (AMA)
Bermeo, Gabriela& Ibarra, Antonio& García, Elisa& Flores-Romero, Adrian& Rico-Rosillo, Guadalupe& Marroquín, Rubén…[et al.]. Monocyte Locomotion Inhibitory Factor Produced by E. histolytica Improves Motor Recovery and Develops Neuroprotection after Traumatic Injury to the Spinal Cord. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-1030412
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030412