![](/images/graphics-bg.png)
Relationship between Vitamin D Receptor Gene Polymorphisms and Migraine without Aura in an Iranian Population
المؤلفون المشاركون
Javanmard, Shaghayegh Haghjooy
Saadatnia, Mohammad
Motaghi, Mohammad
Rafiee, Laleh
Zandifar, Alireza
Haghdoost, Faraidoon
Tajadini, Mohammadhasan
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-25
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Inflammation has a key role in migraine pathophysiology.
Vitamin D is an effective anti-inflammatory agent.
The aim of this study was to investigate the association between migraine and two vitamin D receptor (VDR) polymorphisms (TaqI and FokI) and also the relationship between VDR polymorphisms and headache severity.
Methods.
In this case-control study we assessed 103 patients with newly diagnosed migraine without aura and 100 healthy subjects.
Patients filled headache impact test-6 (HIT-6) as a tool to assess headache severity.
Results.
Genotype frequencies of VDR were significantly different between control and migraine patients.
Heterozygote genotypes (Ff and Tt) were statistically more frequent in the migraine patients than the control subjects both for TaqI gene (P=0.018; OR = 1.81, 95% CI = 1.03–3.18) and FokI gene polymorphisms (P=0.001; OR = 2.91, 95% CI = 1.47–5.77).
Also f and t alleles were more frequent in the migraine patients.
Total HIT-6 score was significantly different between FokI heterozygote and homozygote patients (60.32±1.87 versus 49.87±2.69, resp., P=0.004).
Conclusions.
In conclusion our results showed that TaqI and FokI gene polymorphisms are associated with migraine without aura in Iranians patients.
Also headache severity in FokI heterozygote patients was significantly greater than in the homozygote patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Motaghi, Mohammad& Javanmard, Shaghayegh Haghjooy& Haghdoost, Faraidoon& Tajadini, Mohammadhasan& Saadatnia, Mohammad& Rafiee, Laleh…[et al.]. 2013. Relationship between Vitamin D Receptor Gene Polymorphisms and Migraine without Aura in an Iranian Population. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030428
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Motaghi, Mohammad…[et al.]. Relationship between Vitamin D Receptor Gene Polymorphisms and Migraine without Aura in an Iranian Population. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030428
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Motaghi, Mohammad& Javanmard, Shaghayegh Haghjooy& Haghdoost, Faraidoon& Tajadini, Mohammadhasan& Saadatnia, Mohammad& Rafiee, Laleh…[et al.]. Relationship between Vitamin D Receptor Gene Polymorphisms and Migraine without Aura in an Iranian Population. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030428
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030428
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)