Relationship between Vitamin D Receptor Gene Polymorphisms and Migraine without Aura in an Iranian Population
Joint Authors
Javanmard, Shaghayegh Haghjooy
Saadatnia, Mohammad
Motaghi, Mohammad
Rafiee, Laleh
Zandifar, Alireza
Haghdoost, Faraidoon
Tajadini, Mohammadhasan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Inflammation has a key role in migraine pathophysiology.
Vitamin D is an effective anti-inflammatory agent.
The aim of this study was to investigate the association between migraine and two vitamin D receptor (VDR) polymorphisms (TaqI and FokI) and also the relationship between VDR polymorphisms and headache severity.
Methods.
In this case-control study we assessed 103 patients with newly diagnosed migraine without aura and 100 healthy subjects.
Patients filled headache impact test-6 (HIT-6) as a tool to assess headache severity.
Results.
Genotype frequencies of VDR were significantly different between control and migraine patients.
Heterozygote genotypes (Ff and Tt) were statistically more frequent in the migraine patients than the control subjects both for TaqI gene (P=0.018; OR = 1.81, 95% CI = 1.03–3.18) and FokI gene polymorphisms (P=0.001; OR = 2.91, 95% CI = 1.47–5.77).
Also f and t alleles were more frequent in the migraine patients.
Total HIT-6 score was significantly different between FokI heterozygote and homozygote patients (60.32±1.87 versus 49.87±2.69, resp., P=0.004).
Conclusions.
In conclusion our results showed that TaqI and FokI gene polymorphisms are associated with migraine without aura in Iranians patients.
Also headache severity in FokI heterozygote patients was significantly greater than in the homozygote patients.
American Psychological Association (APA)
Motaghi, Mohammad& Javanmard, Shaghayegh Haghjooy& Haghdoost, Faraidoon& Tajadini, Mohammadhasan& Saadatnia, Mohammad& Rafiee, Laleh…[et al.]. 2013. Relationship between Vitamin D Receptor Gene Polymorphisms and Migraine without Aura in an Iranian Population. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030428
Modern Language Association (MLA)
Motaghi, Mohammad…[et al.]. Relationship between Vitamin D Receptor Gene Polymorphisms and Migraine without Aura in an Iranian Population. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030428
American Medical Association (AMA)
Motaghi, Mohammad& Javanmard, Shaghayegh Haghjooy& Haghdoost, Faraidoon& Tajadini, Mohammadhasan& Saadatnia, Mohammad& Rafiee, Laleh…[et al.]. Relationship between Vitamin D Receptor Gene Polymorphisms and Migraine without Aura in an Iranian Population. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030428
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030428