Genome-Wide Analysis of Human MicroRNA Stability
المؤلفون المشاركون
Li, Yang
Li, Zhixin
Zhou, Shixin
Wen, Jinhua
Geng, Bin
Yang, Jichun
Cui, Q.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-28
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Increasing studies have shown that microRNA (miRNA) stability plays important roles in physiology.
However, the global picture of miRNA stability remains largely unknown.
Here, we had analyzed genome-wide miRNA stability across 10 diverse cell types using miRNA arrays.
We found that miRNA stability shows high dynamics and diversity both within individual cells and across cell types.
Strikingly, we observed a negative correlation between miRNA stability and miRNA expression level, which is different from current findings on other biological molecules such as proteins and mRNAs that show positive and not negative correlations between stability and expression level.
This finding indicates that miRNA has a distinct action mode, which we called “rapid production, rapid turnover; slow production, slow turnover.” This mode further suggests that high expression miRNAs normally degrade fast and may endow the cell with special properties that facilitate cellular status-transition.
Moreover, we revealed that the stability of miRNAs is affected by cohorts of factors that include miRNA targets, transcription factors, nucleotide content, evolution, associated disease, and environmental factors.
Together, our results provided an extensive description of the global landscape, dynamics, and distinct mode of human miRNA stability, which provide help in investigating their functions in physiology and pathophysiology.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yang& Li, Zhixin& Zhou, Shixin& Wen, Jinhua& Geng, Bin& Yang, Jichun…[et al.]. 2013. Genome-Wide Analysis of Human MicroRNA Stability. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030443
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yang…[et al.]. Genome-Wide Analysis of Human MicroRNA Stability. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030443
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yang& Li, Zhixin& Zhou, Shixin& Wen, Jinhua& Geng, Bin& Yang, Jichun…[et al.]. Genome-Wide Analysis of Human MicroRNA Stability. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030443
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030443
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر