Genome-Wide Analysis of Human MicroRNA Stability
Joint Authors
Li, Yang
Li, Zhixin
Zhou, Shixin
Wen, Jinhua
Geng, Bin
Yang, Jichun
Cui, Q.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Increasing studies have shown that microRNA (miRNA) stability plays important roles in physiology.
However, the global picture of miRNA stability remains largely unknown.
Here, we had analyzed genome-wide miRNA stability across 10 diverse cell types using miRNA arrays.
We found that miRNA stability shows high dynamics and diversity both within individual cells and across cell types.
Strikingly, we observed a negative correlation between miRNA stability and miRNA expression level, which is different from current findings on other biological molecules such as proteins and mRNAs that show positive and not negative correlations between stability and expression level.
This finding indicates that miRNA has a distinct action mode, which we called “rapid production, rapid turnover; slow production, slow turnover.” This mode further suggests that high expression miRNAs normally degrade fast and may endow the cell with special properties that facilitate cellular status-transition.
Moreover, we revealed that the stability of miRNAs is affected by cohorts of factors that include miRNA targets, transcription factors, nucleotide content, evolution, associated disease, and environmental factors.
Together, our results provided an extensive description of the global landscape, dynamics, and distinct mode of human miRNA stability, which provide help in investigating their functions in physiology and pathophysiology.
American Psychological Association (APA)
Li, Yang& Li, Zhixin& Zhou, Shixin& Wen, Jinhua& Geng, Bin& Yang, Jichun…[et al.]. 2013. Genome-Wide Analysis of Human MicroRNA Stability. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030443
Modern Language Association (MLA)
Li, Yang…[et al.]. Genome-Wide Analysis of Human MicroRNA Stability. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030443
American Medical Association (AMA)
Li, Yang& Li, Zhixin& Zhou, Shixin& Wen, Jinhua& Geng, Bin& Yang, Jichun…[et al.]. Genome-Wide Analysis of Human MicroRNA Stability. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030443
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030443