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Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance
المؤلفون المشاركون
Yadav, Narayan Prasad
Jain, Sanyog
Sinha, Priyam
Rai, Vineet Kumar
Yadav, Kuldeep Singh
Arora, Sumit
Mishra, Nidhi
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-28
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Liver is a vital organ responsible for plethora of functions including detoxification, protein synthesis, and the production of biochemicals necessary for the sustenance of life.
Therefore, patients with chronic liver diseases such as viral hepatitis, liver cirrhosis, and hepatocellular carcinoma need immediate attention to sustain life and as a result are often exposed to the prolonged treatment with drugs/herbal medications.
Lack of site-specific delivery of these medications to the hepatocytes/nonparenchymal cells and adverse effects associated with their off-target interactions limit their continuous use.
This calls for the development and fabrication of targeted delivery systems which can deliver the drug payload at the desired site of action for defined period of time.
The primary aim of drug targeting is to manipulate the whole body distribution of drugs, that is, to prevent distribution to non-target cells and concomitantly increase the drug concentration at the targeted site.
Carrier molecules are designed for their selective cellular uptake, taking advantage of specific receptors or binding sites present on the surface membrane of the target cell.
In this review, various aspects of liver targeting of drug molecules and herbal medications have been discussed which elucidate the importance of delivering the drugs/herbal medications at their desired site of action.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mishra, Nidhi& Yadav, Narayan Prasad& Rai, Vineet Kumar& Sinha, Priyam& Yadav, Kuldeep Singh& Jain, Sanyog…[et al.]. 2013. Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance. BioMed Research International،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1030474
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mishra, Nidhi…[et al.]. Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance. BioMed Research International No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-1030474
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mishra, Nidhi& Yadav, Narayan Prasad& Rai, Vineet Kumar& Sinha, Priyam& Yadav, Kuldeep Singh& Jain, Sanyog…[et al.]. Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1030474
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030474
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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