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Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance
Joint Authors
Yadav, Narayan Prasad
Jain, Sanyog
Sinha, Priyam
Rai, Vineet Kumar
Yadav, Kuldeep Singh
Arora, Sumit
Mishra, Nidhi
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-28
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Liver is a vital organ responsible for plethora of functions including detoxification, protein synthesis, and the production of biochemicals necessary for the sustenance of life.
Therefore, patients with chronic liver diseases such as viral hepatitis, liver cirrhosis, and hepatocellular carcinoma need immediate attention to sustain life and as a result are often exposed to the prolonged treatment with drugs/herbal medications.
Lack of site-specific delivery of these medications to the hepatocytes/nonparenchymal cells and adverse effects associated with their off-target interactions limit their continuous use.
This calls for the development and fabrication of targeted delivery systems which can deliver the drug payload at the desired site of action for defined period of time.
The primary aim of drug targeting is to manipulate the whole body distribution of drugs, that is, to prevent distribution to non-target cells and concomitantly increase the drug concentration at the targeted site.
Carrier molecules are designed for their selective cellular uptake, taking advantage of specific receptors or binding sites present on the surface membrane of the target cell.
In this review, various aspects of liver targeting of drug molecules and herbal medications have been discussed which elucidate the importance of delivering the drugs/herbal medications at their desired site of action.
American Psychological Association (APA)
Mishra, Nidhi& Yadav, Narayan Prasad& Rai, Vineet Kumar& Sinha, Priyam& Yadav, Kuldeep Singh& Jain, Sanyog…[et al.]. 2013. Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance. BioMed Research International،Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1030474
Modern Language Association (MLA)
Mishra, Nidhi…[et al.]. Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance. BioMed Research International No. 2013 (2013), pp.1-20.
https://search.emarefa.net/detail/BIM-1030474
American Medical Association (AMA)
Mishra, Nidhi& Yadav, Narayan Prasad& Rai, Vineet Kumar& Sinha, Priyam& Yadav, Kuldeep Singh& Jain, Sanyog…[et al.]. Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-20.
https://search.emarefa.net/detail/BIM-1030474
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030474