Relationship between Circulating BAFF Serum Levels with Proliferating Markers in Patients with Multiple Myeloma
المؤلفون المشاركون
Roussou, Paraskevi
Alexandrakis, Michael G.
Pappa, Constantina A.
Messaritakis, Ippokratis
Xekalou, Athina
Goulidaki, Nektaria
Boula, Anna
Tsirakis, George
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-15
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
In multiple myeloma, there are many factors influencing the growth of the malignant clone in direct and indirect manners.
BAFF is a growth factor for myeloma cells.
The aim of the study was to measure its circulating levels in 54 pretreatment patients, along with serum levels of other proliferation markers, such as interleukins-6, -10, and -15, CRP, and beta-2 microglobulin, as well as bone marrow plasma cell infiltration and expression of Ki-67 PI, in various stages of the disease and after effective treatment in 28 of them.
Serum levels of the previously mentioned factors were measured by ELISA, whereas bone marrow plasma cell infiltration and Ki-67 expression were estimated immunohistochemically.
All measured parameters were higher in pretreated myeloma patients compared to healthy population and were also increasing with the progression of the disease.
They all also decreased after effective therapy.
Furthermore, all pretreatment values correlated to each other.
BAFF seems to be an important growth factor for myeloma plasma cells.
Measuring its serum levels, along with the previously mentioned cytokines, may provide important information regarding the degree of myeloma cells’ proliferation.
Therefore, they all could be used as markers of proliferation and disease activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alexandrakis, Michael G.& Roussou, Paraskevi& Pappa, Constantina A.& Messaritakis, Ippokratis& Xekalou, Athina& Goulidaki, Nektaria…[et al.]. 2013. Relationship between Circulating BAFF Serum Levels with Proliferating Markers in Patients with Multiple Myeloma. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030492
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alexandrakis, Michael G.…[et al.]. Relationship between Circulating BAFF Serum Levels with Proliferating Markers in Patients with Multiple Myeloma. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030492
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alexandrakis, Michael G.& Roussou, Paraskevi& Pappa, Constantina A.& Messaritakis, Ippokratis& Xekalou, Athina& Goulidaki, Nektaria…[et al.]. Relationship between Circulating BAFF Serum Levels with Proliferating Markers in Patients with Multiple Myeloma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030492
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030492
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر