Relationship between Circulating BAFF Serum Levels with Proliferating Markers in Patients with Multiple Myeloma
Joint Authors
Roussou, Paraskevi
Alexandrakis, Michael G.
Pappa, Constantina A.
Messaritakis, Ippokratis
Xekalou, Athina
Goulidaki, Nektaria
Boula, Anna
Tsirakis, George
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-07-15
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
In multiple myeloma, there are many factors influencing the growth of the malignant clone in direct and indirect manners.
BAFF is a growth factor for myeloma cells.
The aim of the study was to measure its circulating levels in 54 pretreatment patients, along with serum levels of other proliferation markers, such as interleukins-6, -10, and -15, CRP, and beta-2 microglobulin, as well as bone marrow plasma cell infiltration and expression of Ki-67 PI, in various stages of the disease and after effective treatment in 28 of them.
Serum levels of the previously mentioned factors were measured by ELISA, whereas bone marrow plasma cell infiltration and Ki-67 expression were estimated immunohistochemically.
All measured parameters were higher in pretreated myeloma patients compared to healthy population and were also increasing with the progression of the disease.
They all also decreased after effective therapy.
Furthermore, all pretreatment values correlated to each other.
BAFF seems to be an important growth factor for myeloma plasma cells.
Measuring its serum levels, along with the previously mentioned cytokines, may provide important information regarding the degree of myeloma cells’ proliferation.
Therefore, they all could be used as markers of proliferation and disease activity.
American Psychological Association (APA)
Alexandrakis, Michael G.& Roussou, Paraskevi& Pappa, Constantina A.& Messaritakis, Ippokratis& Xekalou, Athina& Goulidaki, Nektaria…[et al.]. 2013. Relationship between Circulating BAFF Serum Levels with Proliferating Markers in Patients with Multiple Myeloma. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030492
Modern Language Association (MLA)
Alexandrakis, Michael G.…[et al.]. Relationship between Circulating BAFF Serum Levels with Proliferating Markers in Patients with Multiple Myeloma. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030492
American Medical Association (AMA)
Alexandrakis, Michael G.& Roussou, Paraskevi& Pappa, Constantina A.& Messaritakis, Ippokratis& Xekalou, Athina& Goulidaki, Nektaria…[et al.]. Relationship between Circulating BAFF Serum Levels with Proliferating Markers in Patients with Multiple Myeloma. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030492
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030492