Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency
المؤلفون المشاركون
Maisch, Tim
Felgenträger, Ariane
Dobler, Daniel
Späth, Andreas
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-30
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Photodynamic inactivation of bacteria (PIB) by efficient singlet oxygen photosensitizers might be a beneficial alternative to antibiotics in the struggle against multiresistant bacteria.
Phenothiazinium dyes belong to the most prominent classes of such sensitizers due to their intense absorption in the red-light region (λabs, max ca.
600–680 nm, ε>50000 L mol−1 cm−1), their low toxicity, and their attachment/penetration abilities.
Except simple substituents like alkyl or hydroxyalkyl residues, nearly no modifications of the phenothiaziniums have been pursued at the auxochromic sites.
By this, the properties of methylene blue derivatives and their fields of application are limited; it remains unclear if their potential antimicrobial efficacy may be enhanced, also to compete with porphyrins.
We prepared a set of six mainly novel methylene blue derivatives with the ability of additional hydrogen bonding and/or additional cationic charges to study the substituents’ effect on their activity/toxicity profiles and photophysical properties.
Direct detection of singlet oxygen was performed at 1270 nm and the singlet oxygen quantum yields were determined.
In suspensions with both, Gram-positive and Gram-negative bacteria, some derivatives were highly active upon illumination to inactivate S.
aureus and E.
coli up to 7 log10 steps (99.99999%) without inherent toxicities in the nonirradiated state.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Felgenträger, Ariane& Maisch, Tim& Dobler, Daniel& Späth, Andreas. 2012. Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030582
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Maisch, Tim…[et al.]. Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030582
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Felgenträger, Ariane& Maisch, Tim& Dobler, Daniel& Späth, Andreas. Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030582
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030582
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر