Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency
Joint Authors
Maisch, Tim
Felgenträger, Ariane
Dobler, Daniel
Späth, Andreas
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Photodynamic inactivation of bacteria (PIB) by efficient singlet oxygen photosensitizers might be a beneficial alternative to antibiotics in the struggle against multiresistant bacteria.
Phenothiazinium dyes belong to the most prominent classes of such sensitizers due to their intense absorption in the red-light region (λabs, max ca.
600–680 nm, ε>50000 L mol−1 cm−1), their low toxicity, and their attachment/penetration abilities.
Except simple substituents like alkyl or hydroxyalkyl residues, nearly no modifications of the phenothiaziniums have been pursued at the auxochromic sites.
By this, the properties of methylene blue derivatives and their fields of application are limited; it remains unclear if their potential antimicrobial efficacy may be enhanced, also to compete with porphyrins.
We prepared a set of six mainly novel methylene blue derivatives with the ability of additional hydrogen bonding and/or additional cationic charges to study the substituents’ effect on their activity/toxicity profiles and photophysical properties.
Direct detection of singlet oxygen was performed at 1270 nm and the singlet oxygen quantum yields were determined.
In suspensions with both, Gram-positive and Gram-negative bacteria, some derivatives were highly active upon illumination to inactivate S.
aureus and E.
coli up to 7 log10 steps (99.99999%) without inherent toxicities in the nonirradiated state.
American Psychological Association (APA)
Felgenträger, Ariane& Maisch, Tim& Dobler, Daniel& Späth, Andreas. 2012. Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency. BioMed Research International،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030582
Modern Language Association (MLA)
Maisch, Tim…[et al.]. Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency. BioMed Research International No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-1030582
American Medical Association (AMA)
Felgenträger, Ariane& Maisch, Tim& Dobler, Daniel& Späth, Andreas. Hydrogen Bond Acceptors and Additional Cationic Charges in Methylene Blue Derivatives: Photophysics and Antimicrobial Efficiency. BioMed Research International. 2012. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-1030582
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030582