Cytotoxicity of Ferulic Acid on T24 Cell Line Differentiated by Different Microenvironments
المؤلفون المشاركون
Chang, Chi-Huang
Chen, Kuan-Chou
Chyau, Charng-Cherng
Wang, Hui-Er
Peng, Chiung-Chi
Peng, Robert Y.
Chou, Kuang-Yu
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-08
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Ferulic acid (4-hydroxy-3-methoxycinnamic acid) (FA) is a ubiquitous health beneficial phenolic acid.
Although FA has shown a diversity of biological activities including anti-inflammatory,antihypercholesterolemic and anticancer bioactivities, studies revealing its adverse effects are accumulating.
Recently, 3D-cultures are shown to exhibit uniquely biological behaviors different from that of 2D cultures.
To understand whether the cytotoxicity of FA against the T24 cell line (a bladder cancer cell line) in 2D-culture could consistently retain similar bioactivity if cultured in the 3D-systems, we conducted this experiment with 2 mM FA.
Much higher cytotoxicity was found for 3D- than 2D-culture, showing (2D vs.
3D): apoptotic rates, 64% and 76%; cell killing rates, 3.00×105 cells mmol−1·h−1 and 2.63×106 cells mmol−1·h−1, attaining a 8.77-fold.
FA upregulated the activities at 72 h (2D vs.
3D in folds that of control): SOD, 1.73-folds (P<0.05) versus 3.18 folds (P<0.001); and catalase, 2.58 versus 1.33-folds.
Comparing to the control (without FA), Bcl-2 was prominently downregulated while Bax, caspase-3 and cleaved caspase-9 were more upregulated in 3D-cultures (P<0.05).
Conclusively, different microenvironments could elicit different biological significance which in part can be ascribed to different mass transport rate.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Peng, Chiung-Chi& Chyau, Charng-Cherng& Wang, Hui-Er& Chang, Chi-Huang& Chen, Kuan-Chou& Chou, Kuang-Yu…[et al.]. 2013. Cytotoxicity of Ferulic Acid on T24 Cell Line Differentiated by Different Microenvironments. BioMed Research International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030680
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Peng, Chiung-Chi…[et al.]. Cytotoxicity of Ferulic Acid on T24 Cell Line Differentiated by Different Microenvironments. BioMed Research International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-1030680
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Peng, Chiung-Chi& Chyau, Charng-Cherng& Wang, Hui-Er& Chang, Chi-Huang& Chen, Kuan-Chou& Chou, Kuang-Yu…[et al.]. Cytotoxicity of Ferulic Acid on T24 Cell Line Differentiated by Different Microenvironments. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-1030680
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030680
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر