Modulation of Pineal Melatonin Synthesis by Glutamate Involves Paracrine Interactions between Pinealocytes and Astrocytes through NF-κB Activation
المؤلفون المشاركون
Villela, Darine
Atherino, Victoria Fairbanks
Lima, Larissa de Sá
Moutinho, Anderson Augusto
Peres, Rafael
Martins de Lima, Thais
Torrão, Andréa da Silva
Scavone, Cristóforo
Afeche, Solange Castro
Cipolla-Neto, Jose
Amaral, Fernanda G.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-05
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The glutamatergic modulation of melatonin synthesis is well known, along with the importance of astrocytes in mediating glutamatergic signaling in the central nervous system.
Pinealocytes and astrocytes are the main cell types in the pineal gland.
The objective of this work was to investigate the interactions between astrocytes and pinealocytes as a part of the glutamate inhibitory effect on melatonin synthesis.
Rat pinealocytes isolated or in coculture with astrocytes were incubated with glutamate in the presence of norepinephrine, and the melatonin content, was quantified.
The expression of glutamate receptors, the intracellular calcium content and the NF-κB activation were analyzed in astrocytes and pinealocytes.
TNF-α's possible mediation of the effect of glutamate was also investigated.
The results showed that glutamate's inhibitory effect on melatonin synthesis involves interactions between astrocytes and pinealocytes, possibly through the release of TNF-α.
Moreover, the activation of the astrocytic NF-κB seems to be a necessary step.
In astrocytes and pinealocytes, AMPA, NMDA, and group I metabotropic glutamate receptors were observed, as well as the intracellular calcium elevation.
In conclusion, there is evidence that the modulation of melatonin synthesis by glutamate involves paracrine interactions between pinealocytes and astrocytes through the activation of the astrocytic NF-κB transcription factor and possibly by subsequent TNF-α release.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Villela, Darine& Atherino, Victoria Fairbanks& Lima, Larissa de Sá& Moutinho, Anderson Augusto& Amaral, Fernanda G.& Peres, Rafael…[et al.]. 2013. Modulation of Pineal Melatonin Synthesis by Glutamate Involves Paracrine Interactions between Pinealocytes and Astrocytes through NF-κB Activation. BioMed Research International،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030722
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Villela, Darine…[et al.]. Modulation of Pineal Melatonin Synthesis by Glutamate Involves Paracrine Interactions between Pinealocytes and Astrocytes through NF-κB Activation. BioMed Research International No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-1030722
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Villela, Darine& Atherino, Victoria Fairbanks& Lima, Larissa de Sá& Moutinho, Anderson Augusto& Amaral, Fernanda G.& Peres, Rafael…[et al.]. Modulation of Pineal Melatonin Synthesis by Glutamate Involves Paracrine Interactions between Pinealocytes and Astrocytes through NF-κB Activation. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-1030722
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030722
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر