Role of Corneal Epithelium in RiboflavinUltraviolet-A Mediated Corneal Cross-Linking Treatment in Rabbit Eyes

المؤلفون المشاركون

Mu, Guoying
Tao, Xiangchen
Yu, Haiqun
Zhang, Yong
Ni, Shouxiang
Wang, Ya
Jhanji, Vishal
Li, Zhiwei

المصدر

BioMed Research International

العدد

المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2013-06-27

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

Purpose.

To evaluate the role of corneal epithelium in riboflavin/ultraviolet-A (UVA) mediated corneal collagen cross-linking treatment.

Methods.

Fifty New Zealand rabbits were divided into 5 groups: UVA treatment with or without corneal epithelium, UVA+riboflavin treatment with or without corneal epithelium, and control without any treatment.

All rabbits were sacrificed after irradiation and subsequently 4 mm × 10 mm corneal strips were harvested for biomechanical evaluation.

Results.

UVA irradiation alone did not enhance the maximal stress and Young’s modulus of corneal specimens with (3.15 ± 0.56 mpa, 1.00 ± 0.09 mpa) or without (3.53 ± 0.85 mpa, 0.94 ± 0.21 mpa) the corneal epithelium, compared to specimens in the control group (4.30 ± 0.68 mpa, 1.03 ± 0.24 mpa).

However, UVA irradiation combined with riboflavin significantly increased the maximal stress and Young’s modulus of corneal specimens with (5.27 ± 1.09 mpa, 1.23 ± 0.23 mpa, P<0.05) or without (7.16 ± 1.88 mpa, 1.42 ± 0.16 mpa, P<0.05) corneal epithelium when compared to the control group.

The maximal stress and Young’s modulus of cornea in UVA+riboflavin and “epithelium-off” group were 35.9% and 15.4% higher compared to the UVA+riboflavin and “epithelium-on” group, respectively (P<0.05).

Conclusions.

Our study shows that UVA+riboflavin treatment significantly affects the biomechanical properties of the cornea with and without epithelial removal.

However, corneas without epithelium seem to benefit more compared to corneas with the epithelium.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Tao, Xiangchen& Yu, Haiqun& Zhang, Yong& Li, Zhiwei& Jhanji, Vishal& Ni, Shouxiang…[et al.]. 2013. Role of Corneal Epithelium in RiboflavinUltraviolet-A Mediated Corneal Cross-Linking Treatment in Rabbit Eyes. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030728

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Tao, Xiangchen…[et al.]. Role of Corneal Epithelium in RiboflavinUltraviolet-A Mediated Corneal Cross-Linking Treatment in Rabbit Eyes. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030728

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Tao, Xiangchen& Yu, Haiqun& Zhang, Yong& Li, Zhiwei& Jhanji, Vishal& Ni, Shouxiang…[et al.]. Role of Corneal Epithelium in RiboflavinUltraviolet-A Mediated Corneal Cross-Linking Treatment in Rabbit Eyes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030728

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1030728