Role of Corneal Epithelium in RiboflavinUltraviolet-A Mediated Corneal Cross-Linking Treatment in Rabbit Eyes
Joint Authors
Mu, Guoying
Tao, Xiangchen
Yu, Haiqun
Zhang, Yong
Ni, Shouxiang
Wang, Ya
Jhanji, Vishal
Li, Zhiwei
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
To evaluate the role of corneal epithelium in riboflavin/ultraviolet-A (UVA) mediated corneal collagen cross-linking treatment.
Methods.
Fifty New Zealand rabbits were divided into 5 groups: UVA treatment with or without corneal epithelium, UVA+riboflavin treatment with or without corneal epithelium, and control without any treatment.
All rabbits were sacrificed after irradiation and subsequently 4 mm × 10 mm corneal strips were harvested for biomechanical evaluation.
Results.
UVA irradiation alone did not enhance the maximal stress and Young’s modulus of corneal specimens with (3.15 ± 0.56 mpa, 1.00 ± 0.09 mpa) or without (3.53 ± 0.85 mpa, 0.94 ± 0.21 mpa) the corneal epithelium, compared to specimens in the control group (4.30 ± 0.68 mpa, 1.03 ± 0.24 mpa).
However, UVA irradiation combined with riboflavin significantly increased the maximal stress and Young’s modulus of corneal specimens with (5.27 ± 1.09 mpa, 1.23 ± 0.23 mpa, P<0.05) or without (7.16 ± 1.88 mpa, 1.42 ± 0.16 mpa, P<0.05) corneal epithelium when compared to the control group.
The maximal stress and Young’s modulus of cornea in UVA+riboflavin and “epithelium-off” group were 35.9% and 15.4% higher compared to the UVA+riboflavin and “epithelium-on” group, respectively (P<0.05).
Conclusions.
Our study shows that UVA+riboflavin treatment significantly affects the biomechanical properties of the cornea with and without epithelial removal.
However, corneas without epithelium seem to benefit more compared to corneas with the epithelium.
American Psychological Association (APA)
Tao, Xiangchen& Yu, Haiqun& Zhang, Yong& Li, Zhiwei& Jhanji, Vishal& Ni, Shouxiang…[et al.]. 2013. Role of Corneal Epithelium in RiboflavinUltraviolet-A Mediated Corneal Cross-Linking Treatment in Rabbit Eyes. BioMed Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030728
Modern Language Association (MLA)
Tao, Xiangchen…[et al.]. Role of Corneal Epithelium in RiboflavinUltraviolet-A Mediated Corneal Cross-Linking Treatment in Rabbit Eyes. BioMed Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-1030728
American Medical Association (AMA)
Tao, Xiangchen& Yu, Haiqun& Zhang, Yong& Li, Zhiwei& Jhanji, Vishal& Ni, Shouxiang…[et al.]. Role of Corneal Epithelium in RiboflavinUltraviolet-A Mediated Corneal Cross-Linking Treatment in Rabbit Eyes. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-1030728
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1030728