An Approach for Identifying Cytokines Based on a Novel Ensemble Classifier
المؤلفون المشاركون
Zou, Quan
Wang, Zhen
Guan, Xinjun
Liu, Bin
Wu, Yunfeng
Lin, Ziyu
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Biology is meaningful and important to identify cytokines and investigate their various functions and biochemical mechanisms.
However, several issues remain, including the large scale of benchmark datasets, serious imbalance of data, and discovery of new gene families.
In this paper, we employ the machine learning approach based on a novel ensemble classifier to predict cytokines.
We directly selected amino acids sequences as research objects.
First, we pretreated the benchmark data accurately.
Next, we analyzed the physicochemical properties and distribution of whole amino acids and then extracted a group of 120-dimensional (120D) valid features to represent sequences.
Third, in the view of the serious imbalance in benchmark datasets, we utilized a sampling approach based on the synthetic minority oversampling technique algorithm and K-means clustering undersampling algorithm to rebuild the training set.
Finally, we built a library for dynamic selection and circulating combination based on clustering (LibD3C) and employed the new training set to realize cytokine classification.
Experiments showed that the geometric mean of sensitivity and specificity obtained through our approach is as high as 93.3%, which proves that our approach is effective for identifying cytokines.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zou, Quan& Wang, Zhen& Guan, Xinjun& Liu, Bin& Wu, Yunfeng& Lin, Ziyu. 2013. An Approach for Identifying Cytokines Based on a Novel Ensemble Classifier. BioMed Research International،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030790
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zou, Quan…[et al.]. An Approach for Identifying Cytokines Based on a Novel Ensemble Classifier. BioMed Research International No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-1030790
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zou, Quan& Wang, Zhen& Guan, Xinjun& Liu, Bin& Wu, Yunfeng& Lin, Ziyu. An Approach for Identifying Cytokines Based on a Novel Ensemble Classifier. BioMed Research International. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-1030790
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1030790
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر